| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
|---|
| Ligand | BDBM82551 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1926745 (CHEMBL4429817) |
|---|
| IC50 | 2.9±n/a nM |
|---|
| Citation |  Váradi, A; Marrone, GF; Palmer, TC; Narayan, A; Szabó, MR; Le Rouzic, V; Grinnell, SG; Subrath, JJ; Warner, E; Kalra, S; Hunkele, A; Pagirsky, J; Eans, SO; Medina, JM; Xu, J; Pan, YX; Borics, A; Pasternak, GW; McLaughlin, JP; Majumdar, S Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit ?-Arrestin-2. J Med Chem59:8381-97 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Kappa-type opioid receptor |
|---|
| Name: | Kappa-type opioid receptor |
|---|
| Synonyms: | KOR-1 | MSL-1 | OPIATE Kappa | OPRK_MOUSE | Oprk1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 42656.78 |
|---|
| Organism: | Mus musculus (Mouse) |
|---|
| Description: | P33534 |
|---|
| Residue: | 380 |
|---|
| Sequence: | MESPIQIFRGDPGPTCSPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLESAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRV
RNTVQDPASMRDVGGMNKPV
|
|
|
|---|
| BDBM82551 |
|---|
| n/a |
|---|
| Name | BDBM82551 |
|---|
| Synonyms: | C18130 | CAS_105618-26-6 | NOR-BNI (HCI)2 | NORBNI |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C40H43N3O6 |
|---|
| Mol. Mass. | 661.7859 |
|---|
| SMILES | Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)c1[nH]c2[C@@H]4Oc6c7c(C[C@H]8N(CC9CC9)CC[C@@]47[C@@]8(O)Cc2c1C[C@@]35O)ccc6O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
