| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 2 |
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| Ligand | BDBM50091451 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_41896 |
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| Ki | 360±n/a nM |
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| Citation |  Forbes, IT; Cooper, DG; Dodds, EK; Hickey, DM; Ife, RJ; Meeson, M; Stockley, M; Berkhout, TA; Gohil, J; Groot, PH; Moores, K CCR2B receptor antagonists: conversion of a weak HTS hit to a potent lead compound. Bioorg Med Chem Lett10:1803-6 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 2 |
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| Name: | C-C chemokine receptor type 2 |
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| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 41932.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41597 |
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| Residue: | 374 |
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| Sequence: | MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
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| BDBM50091451 |
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| n/a |
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| Name | BDBM50091451 |
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| Synonyms: | (E)-3-(3,4-Dichloro-phenyl)-N-{5-[4-(6-hydroxy-1H-indol-3-yl)-piperidin-1-yl]-pentyl}-acrylamide | CHEMBL51332 | TCMDC-139282 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H31Cl2N3O2 |
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| Mol. Mass. | 500.46 |
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| SMILES | Oc1ccc2c(c[nH]c2c1)C1CCN(CCCCCNC(=O)\C=C\c2ccc(Cl)c(Cl)c2)CC1 |
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| Structure | 
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