| Reaction Details |
|---|
 | Report a problem with these data |
| Target | C-1-tetrahydrofolate synthase, cytoplasmic |
|---|
| Ligand | BDBM50535658 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1931012 (CHEMBL4434263) |
|---|
| IC50 | >30000±n/a nM |
|---|
| Citation |  Kawai, J; Ota, M; Ohki, H; Toki, T; Suzuki, M; Shimada, T; Matsui, S; Inoue, H; Sugihara, C; Matsuhashi, N; Matsui, Y; Takaishi, S; Nakayama, K Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold. ACS Med Chem Lett10:893-898 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| C-1-tetrahydrofolate synthase, cytoplasmic |
|---|
| Name: | C-1-tetrahydrofolate synthase, cytoplasmic |
|---|
| Synonyms: | C-1-tetrahydrofolate synthase, cytoplasmic | C1-THF synthase | C1TC_HUMAN | Formyltetrahydrofolate synthetase | MTHFC | MTHFD | MTHFD1 | Methenyltetrahydrofolate cyclohydrolase | Methylenetetrahydrofolate dehydrogenase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 101566.59 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_257 |
|---|
| Residue: | 935 |
|---|
| Sequence: | MAPAEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAA
EEIGIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAP
EKDVDGLTSINAGRLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAP
MHDLLLWNNATVTTCHSKTAHLDEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINY
VPDDKKPNGRKVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAKRFLEKFKP
GKWMIQYNNLNLKTPVPSDIDISRSCKPKPIGKLAREIGLLSEEVELYGETKAKVLLSAL
ERLKHRPDGKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLYQNVFACVRQPSQGPTFGI
KGGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLV
PSVNGVRRFSDIQIRRLKRLGIEKTDPTTLTDEEINRFARLDIDPETITWQRVLDTNDRF
LRKITIGQAPTEKGHTRTAQFDISVASEIMAVLALTTSLEDMRERLGKMVVASSKKGEPV
SAEDLGVSGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVG
PEGFVVTEAGFGADIGMEKFFNIKCRYSGLCPHVVVLVATVRALKMHGGGPTVTAGLPLP
KAYIQENLELVEKGFSNLKKQIENARMFGIPVVVAVNAFKTDTESELDLISRLSREHGAF
DAVKCTHWAEGGKGALALAQAVQRAAQAPSSFQLLYDLKLPVEDKIRIIAQKIYGADDIE
LLPEAQHKAEVYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFILPIRDIRASVGAGFL
YPLVGTMSTMPGLPTRPCFYDIDLDPETEQVNGLF
|
|
|
|---|
| BDBM50535658 |
|---|
| n/a |
|---|
| Name | BDBM50535658 |
|---|
| Synonyms: | CHEMBL4465667 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H19N3O4 |
|---|
| Mol. Mass. | 341.3612 |
|---|
| SMILES | OC(=O)c1ccc(cc1)C(=O)N1CCc2c(C1)c(=O)n1CCCCn21 |
|---|
| Structure | 
|
|---|
Search and Browse
