| Reaction Details |
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 | Report a problem with these data |
| Target | Serine palmitoyltransferase 1 |
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| Ligand | BDBM50535847 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1932328 (CHEMBL4477980) |
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| IC50 | 64±n/a nM |
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| Citation |  Genin, MJ; Gonzalez Valcarcel, IC; Holloway, WG; Lamar, J; Mosior, M; Hawkins, E; Estridge, T; Weidner, J; Seng, T; Yurek, D; Adams, LA; Weller, J; Reynolds, VL; Brozinick, JT Imidazopyridine and Pyrazolopiperidine Derivatives as Novel Inhibitors of Serine Palmitoyl Transferase. J Med Chem59:5904-10 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine palmitoyltransferase 1 |
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| Name: | Serine palmitoyltransferase 1 |
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| Synonyms: | LCB 1 | LCB1 | Long chain base biosynthesis protein 1 | SPT 1 | SPT1 | SPTC1_HUMAN | SPTLC1 | Serine-palmitoyl-CoA transferase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52739.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_660503 |
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| Residue: | 473 |
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| Sequence: | MATATEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERSDLTVKEKEEL
IEEWQPEPLVPPVPKDHPALNYNIVSGPPSHKTVVNGKECINFASFNFLGLLDNPRVKAA
ALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFATIASAIPAYSK
RGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEIEDQKNPRKARVTRR
FIVVEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGINIDDI
DLISANMENALASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENP
GIFAVLKEKCGQIHKALQGISGLKVVGESLSPAFHLQLEESTGSREQDVRLLQEIVDQCM
NRSIALTQARYLEKEEKCLPPPSIRVVVTVEQTEEELERAASTIKEVAQAVLL
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| BDBM50535847 |
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| n/a |
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| Name | BDBM50535847 |
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| Synonyms: | CHEMBL4541898 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H33N3O3 |
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| Mol. Mass. | 411.5371 |
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| SMILES | CCCCCCC(=O)N1CCc2c(C1)c(nn2C)-c1ccc(cc1)C(C)(C)C(O)=O |
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| Structure | 
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