| Reaction Details |
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 | Report a problem with these data |
| Target | Proteasome subunit beta type-5 |
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| Ligand | BDBM50536425 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1933756 (CHEMBL4479408) |
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| IC50 | 2.1±n/a nM |
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| Citation |  Xin, BT; de Bruin, G; Huber, EM; Besse, A; Florea, BI; Filippov, DV; van der Marel, GA; Kisselev, AF; van der Stelt, M; Driessen, C; Groll, M; Overkleeft, HS Structure-Based Design of ?5c Selective Inhibitors of Human Constitutive Proteasomes. J Med Chem59:7177-87 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteasome subunit beta type-5 |
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| Name: | Proteasome subunit beta type-5 |
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| Synonyms: | 20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X |
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| Type: | Protein |
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| Mol. Mass.: | 28480.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 263 |
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| Sequence: | MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGT
TTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLAR
QCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRI
SGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVRE
DGWIRVSSDNVADLHEKYSGSTP
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| BDBM50536425 |
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| n/a |
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| Name | BDBM50536425 |
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| Synonyms: | CHEMBL4563298 |
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| Type | Small organic molecule |
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| Emp. Form. | C37H44N6O6 |
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| Mol. Mass. | 668.7819 |
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| SMILES | COc1ccc(C[C@H](NC(=O)[C@H](Cc2ccccc2)N=[N+]=[N-])C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]2(C)CO2)cc1 |r| |
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| Structure | 
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