| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-beta |
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| Ligand | BDBM50536791 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1934545 (CHEMBL4480197) |
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| EC50 | 5400±n/a nM |
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| Citation |  René, O; Fauber, BP; Barnard, A; Chapman, K; Deng, Y; Eidenschenk, C; Everett, C; Gobbi, A; Johnson, AR; La, H; Norman, M; Salmon, G; Summerhill, S; Wong, H Discovery of oxa-sultams as RORc inverse agonists showing reduced lipophilicity, improved selectivity and favorable ADME properties. Bioorg Med Chem Lett26:4455-4461 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor ROR-beta |
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| Name: | Nuclear receptor ROR-beta |
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| Synonyms: | NR1F2 | Nuclear receptor RZR-beta | Nuclear receptor subfamily 1 group F member 2 | RORB | RORB_HUMAN | RZRB | Retinoid-related orphan receptor-beta |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53227.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107979 |
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| Residue: | 470 |
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| Sequence: | MCENQLKTKADATAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQ
RNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQ
QQSGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGYYNVDSGQPSPDQSG
LDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNIIKSHLETCQY
TMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQN
DQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNL
CSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKL
IAKIPTITAVCNLHGEKLQVFKQSHPEIVNTLFPPLYKELFNPDCATGCK
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| BDBM50536791 |
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| n/a |
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| Name | BDBM50536791 |
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| Synonyms: | CHEMBL4579711 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H30FN3O3S |
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| Mol. Mass. | 459.577 |
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| SMILES | C[C@H]1CC[C@H](c2ccccc2)S(=O)(=O)N1Cc1ccc(cc1F)N1CCN(CC1)C(C)=O |r| |
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| Structure | 
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