Reaction Details |
| Report a problem with these data |
Target | Cysteine protease ATG4B |
---|
Ligand | BDBM50536837 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1934686 (CHEMBL4480338) |
---|
IC50 | 1200±n/a nM |
---|
Citation | Qiu, Z; Kuhn, B; Aebi, J; Lin, X; Ding, H; Zhou, Z; Xu, Z; Xu, D; Han, L; Liu, C; Qiu, H; Zhang, Y; Haap, W; Riemer, C; Stahl, M; Qin, N; Shen, HC; Tang, G Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors. ACS Med Chem Lett7:802-6 (2016) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Cysteine protease ATG4B |
---|
Name: | Cysteine protease ATG4B |
Synonyms: | APG4B | ATG4B | ATG4B_HUMAN | AUTL1 | KIAA0943 | cysteine protease ATG4B isoform a | hck |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 44279.79 |
Organism: | Homo sapiens (Human) |
Description: | gi_47132611 |
Residue: | 393 |
Sequence: | MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPA
IGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKD
SYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIR
RLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYV
ETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFH
CQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQPSHLA
CPDVLNLSLDSSDVERLERFFDSEDEDFEILSL
|
|
|
BDBM50536837 |
---|
n/a |
---|
Name | BDBM50536837 |
Synonyms: | CHEMBL4572200 |
Type | Small organic molecule |
Emp. Form. | C20H21FN2O4 |
Mol. Mass. | 372.3901 |
SMILES | FCC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 |r| |
Structure |
|