| Reaction Details |
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 | Report a problem with these data |
| Target | Cysteine protease ATG4B |
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| Ligand | BDBM50536837 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1934661 (CHEMBL4480313) |
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| IC50 | 1130±n/a nM |
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| Citation |  Qiu, Z; Kuhn, B; Aebi, J; Lin, X; Ding, H; Zhou, Z; Xu, Z; Xu, D; Han, L; Liu, C; Qiu, H; Zhang, Y; Haap, W; Riemer, C; Stahl, M; Qin, N; Shen, HC; Tang, G Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors. ACS Med Chem Lett7:802-6 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cysteine protease ATG4B |
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| Name: | Cysteine protease ATG4B |
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| Synonyms: | APG4B | ATG4B | ATG4B_HUMAN | AUTL1 | KIAA0943 | cysteine protease ATG4B isoform a | hck |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44279.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_47132611 |
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| Residue: | 393 |
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| Sequence: | MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPA
IGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKD
SYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIR
RLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYV
ETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFH
CQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQPSHLA
CPDVLNLSLDSSDVERLERFFDSEDEDFEILSL
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| BDBM50536837 |
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| n/a |
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| Name | BDBM50536837 |
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| Synonyms: | CHEMBL4572200 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21FN2O4 |
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| Mol. Mass. | 372.3901 |
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| SMILES | FCC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 |r| |
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| Structure | 
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