Reaction Details |
| Report a problem with these data |
Target | Lysosomal acid glucosylceramidase |
---|
Ligand | BDBM50537913 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1970833 (CHEMBL4603651) |
---|
EC50 | 1100±n/a nM |
---|
Citation | Childers, W; Fan, R; Martinez, R; Colussi, DJ; Melenski, E; Liu, Y; Gordon, J; Abou-Gharbia, M; Jacobson, MA Novel compounds that reverse the disease phenotype in Type 2 Gaucher disease patient-derived cells. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Lysosomal acid glucosylceramidase |
---|
Name: | Lysosomal acid glucosylceramidase |
Synonyms: | Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GBA1 | GBA1_HUMAN | GC | GCase | GLUC | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase) | Imiglucerase | beta-glucocerebrosidase (GCase) |
Type: | Enzyme |
Mol. Mass.: | 59724.64 |
Organism: | Homo sapiens (Human) |
Description: | The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source. |
Residue: | 536 |
Sequence: | MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNAT
YCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGF
GGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDD
FQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQP
GDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIA
RDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAK
ATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDW
NLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQK
NDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
|
|
|
BDBM50537913 |
---|
n/a |
---|
Name | BDBM50537913 |
Synonyms: | CHEMBL4647988 |
Type | Small organic molecule |
Emp. Form. | C25H35NO2 |
Mol. Mass. | 381.5509 |
SMILES | CC(C)CC(C(=O)c1ccc(OCCN(C)C)cc1)c1ccccc1C(C)C |
Structure |
|