Ki Summary

Reaction Details

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Target

Coiled-coil domain-containing protein 6

Ligand

BDBM50538515

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1973009 (CHEMBL4605827)

IC50

16±n/a nM

Citation

Mathison, CJN; Chianelli, D; Rucker, PV; Nelson, J; Roland, J; Huang, Z; Yang, Y; Jiang, J; Xie, YF; Epple, R; Bursulaya, B; Lee, C; Gao, MY; Shaffer, J; Briones, S; Sarkisova, Y; Galkin, A; Li, L; Li, N; Li, C; Hua, S; Kasibhatla, S; Kinyamu-Akunda, J; Kikkawa, R; Molteni, V; Tellew, JE Efficacy and Tolerability of Pyrazolo[1,5- ACS Med Chem Lett11:558-565 (2020) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Coiled-coil domain-containing protein 6

Name:

Coiled-coil domain-containing protein 6

Synonyms:

Type:

PROTEIN

Mol. Mass.:

53294.85

Organism:

Homo sapiens (Human)

Description:

ChEMBL_109661

Residue:

474

Sequence:

MADSASESDTDGAGGNSSSSAAMQSSCSSTSGGGGGGGGGGGGGKSGGIVISPFRLEELT
NRLASLQQENKVLKIELETYKLKCKALQEENRDLRKASVTIQARAEQEEEFISNTLFKKI
QALQKEKETLAVNYEKEEEFLTNELSRKLMQLQHEKAELEQHLEQEQEFQVNKLMKKIKK
LENDTISKQLTLEQLRREKIDLENTLEQEQEALVNRLWKRMDKLEAEKRILQEKLDQPVS
APPSPRDISMEIDSPENMMRHIRFLKNEVERLKKQLRAAQLQHSEKMAQYLEEERHMREE
NLRLQRKLQREMERREALCRQLSESESSLEMDDERYFNEMSAQGLRPRTVSSPIPYTPSP
SSSRPISPGLSYASHTVGFTPPTSLTRAGMSYYNSPGLHVQHMGTSHGITRPSPRRSNSP
DKFKRPTPPPSPNTQTPVQPPPPPPPPPMQPTVPSAATSQPTPSQHSAHPSSQP

BDBM50538515

n/a

Name

BDBM50538515

Synonyms:

CHEMBL4636056

Type

Small organic molecule

Emp. Form.

C34H41N7O2

Mol. Mass.

579.735

SMILES

[H][C@]12CN(C(=O)c3ccc(cc3)-c3cnn4c(N)c(c(NC5CC(C)(C)N(C)C(C)(C)C5)nc34)-c3ccccc3)[C@]([H])(CO1)C2 |r|

Structure