| Reaction Details |
|---|
 | Report a problem with these data |
| Target | C-X-C chemokine receptor type 6 |
|---|
| Ligand | BDBM50539478 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1978131 (CHEMBL4611266) |
|---|
| IC50 | 260±n/a nM |
|---|
| Citation |  Peddibhotla, S; Hershberger, PM; Jason Kirby, R; Sugarman, E; Maloney, PR; Hampton Sessions, E; Divlianska, D; Morfa, CJ; Terry, D; Pinkerton, AB; Smith, LH; Malany, S Discovery of small molecule antagonists of chemokine receptor CXCR6 that arrest tumor growth in SK-HEP-1 mouse xenografts as a model of hepatocellular carcinoma. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| C-X-C chemokine receptor type 6 |
|---|
| Name: | C-X-C chemokine receptor type 6 |
|---|
| Synonyms: | BONZO | C-X-C chemokine receptor type 6 | CD_antigen=CD186 | CDw186 | CXC-R6 | CXCR-6 | CXCR6 | CXCR6_HUMAN | G-protein coupled receptor STRL33 | G-protein coupled receptor bonzo | STRL33 | TYMSTR |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 39289.05 |
|---|
| Organism: | Homo sapiens |
|---|
| Description: | ChEMBL_102648 |
|---|
| Residue: | 342 |
|---|
| Sequence: | MAEHDYHEDYGFSSFNDSSQEEHQDFLQFSKVFLPCMYLVVFVCGLVGNSLVLVISIFYH
KLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTINFYTSMLIL
TCITVDRFIVVVKATKAYNQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLIC
GYHDEAISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVF
LLTQMPFNLMKFIRSTHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNFW
KLVKDIGCLPYLGVSHQWKSSEDNSKTFSASHNVEATSMFQL
|
|
|
|---|
| BDBM50539478 |
|---|
| n/a |
|---|
| Name | BDBM50539478 |
|---|
| Synonyms: | CHEMBL4638493 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H30ClN3O4S |
|---|
| Mol. Mass. | 516.052 |
|---|
| SMILES | [H][C@]12CCC[C@]([H])(C[C@H](C1)NC(=O)c1cc(OC)c(OC)c(OC)c1)N2Cc1nc2cccc(Cl)c2s1 |r,TLB:10:8:25:4.2.3| |
|---|
| Structure | 
|
|---|
Search and Browse
