Compile Data Set for Download or QSAR

Found 675 hits with Last Name = 'sugarman' and Initial = 'e'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50440737 (CHEMBL2431120) Show SMILES COc1ccccc1N1CCN(CC1)c1nc(nc2cc(OC)c(OC)cc12)C1CC1 Show InChI InChI=1S/C24H28N4O3/c1-29-20-7-5-4-6-19(20)27-10-12-28(13-11-27)24-17-14-21(30-2)22(31-3)15-18(17)25-23(26-24)16-8-9-16/h4-7,14-16H,8-13H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	410	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Conrad Prebys Center for Chemical Genomics at Sanford-Burnham Medical Research Institute Curated by ChEMBL					Assay Description Binding affinity to sigma-1 receptor (unknown origin)				ACS Med Chem Lett 4: 846-851 (2013) Article DOI: 10.1021/ml400176n BindingDB Entry DOI: 10.7270/Q2959JZQ
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 3A (Homo sapiens (Human))	BDBM50440737 (CHEMBL2431120) Show SMILES COc1ccccc1N1CCN(CC1)c1nc(nc2cc(OC)c(OC)cc12)C1CC1 Show InChI InChI=1S/C24H28N4O3/c1-29-20-7-5-4-6-19(20)27-10-12-28(13-11-27)24-17-14-21(30-2)22(31-3)15-18(17)25-23(26-24)16-8-9-16/h4-7,14-16H,8-13H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Conrad Prebys Center for Chemical Genomics at Sanford-Burnham Medical Research Institute Curated by ChEMBL					Assay Description Binding affinity to 5-HT3 receptor (unknown origin)				ACS Med Chem Lett 4: 846-851 (2013) Article DOI: 10.1021/ml400176n BindingDB Entry DOI: 10.7270/Q2959JZQ
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50440737 (CHEMBL2431120) Show SMILES COc1ccccc1N1CCN(CC1)c1nc(nc2cc(OC)c(OC)cc12)C1CC1 Show InChI InChI=1S/C24H28N4O3/c1-29-20-7-5-4-6-19(20)27-10-12-28(13-11-27)24-17-14-21(30-2)22(31-3)15-18(17)25-23(26-24)16-8-9-16/h4-7,14-16H,8-13H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	1.42E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Conrad Prebys Center for Chemical Genomics at Sanford-Burnham Medical Research Institute Curated by ChEMBL					Assay Description Binding affinity to histamine H1 receptor (unknown origin)				ACS Med Chem Lett 4: 846-851 (2013) Article DOI: 10.1021/ml400176n BindingDB Entry DOI: 10.7270/Q2959JZQ
					More data for this Ligand-Target Pair
Translocator protein (Homo sapiens (Human))	BDBM50440737 (CHEMBL2431120) Show SMILES COc1ccccc1N1CCN(CC1)c1nc(nc2cc(OC)c(OC)cc12)C1CC1 Show InChI InChI=1S/C24H28N4O3/c1-29-20-7-5-4-6-19(20)27-10-12-28(13-11-27)24-17-14-21(30-2)22(31-3)15-18(17)25-23(26-24)16-8-9-16/h4-7,14-16H,8-13H2,1-3H3	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	2.54E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Conrad Prebys Center for Chemical Genomics at Sanford-Burnham Medical Research Institute Curated by ChEMBL					Assay Description Binding affinity to PBR receptor (unknown origin)				ACS Med Chem Lett 4: 846-851 (2013) Article DOI: 10.1021/ml400176n BindingDB Entry DOI: 10.7270/Q2959JZQ
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 2 (Homo sapiens (Human))	BDBM50314930 (1-(2-(1-methyl-1H-pyrazol-3-yl)-1H-benzo[d]imidazo...) Show SMILES Cn1ccc(n1)-c1nc2ccc(cc2[nH]1)C(=O)N1CCC2(CC1)CC(=O)c1cc(ncc1O2)-c1cnn(C)c1 Show InChI InChI=1S/C28H26N8O3/c1-34-8-5-21(33-34)26-31-20-4-3-17(11-23(20)32-26)27(38)36-9-6-28(7-10-36)13-24(37)19-12-22(29-15-25(19)39-28)18-14-30-35(2)16-18/h3-5,8,11-12,14-16H,6-7,9-10,13H2,1-2H3,(H,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.210	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human recombinant ACC2 expressed in CHO cells after 1 hr by fluorescence reader				Bioorg Med Chem Lett 20: 2383-8 (2010) Article DOI: 10.1016/j.bmcl.2009.04.091 BindingDB Entry DOI: 10.7270/Q22N52DW
					More data for this Ligand-Target Pair
Neurotensin receptor type 1 (Homo sapiens (Human))	BDBM50440738 (CHEMBL2431105) Show SMILES COc1cccc(OC)c1-c1cc(nn1-c1ccc(cc1C(C)C)C(=O)N(C)CCCN(C)C)C(=O)NC1(C2CC3CC(C2)CC1C3)C(O)=O |TLB:47:37:46:41.44.42,43:38:46:41.44.42,43:42:46:39.38.37,THB:37:38:41:46.44.45,37:45:41:39.38.43,36:37:46:41.44.42,(15.65,-18.65,;16.42,-17.32,;15.65,-15.98,;14.12,-15.98,;13.35,-14.64,;14.12,-13.31,;15.66,-13.32,;16.45,-11.99,;15.69,-10.65,;16.42,-14.66,;17.96,-14.67,;18.44,-16.14,;19.98,-16.13,;20.44,-14.66,;19.21,-13.77,;19.2,-12.24,;17.87,-11.46,;17.87,-9.92,;19.2,-9.15,;20.53,-9.91,;20.53,-11.45,;21.87,-12.22,;23.2,-11.45,;21.87,-13.76,;19.19,-7.61,;17.86,-6.84,;20.52,-6.83,;20.52,-5.29,;21.86,-7.6,;23.19,-6.83,;24.53,-7.6,;25.86,-6.82,;27.2,-7.59,;25.86,-5.28,;20.89,-17.37,;20.27,-18.78,;22.42,-17.2,;23.33,-18.45,;24.37,-19.55,;23.6,-20.77,;22.31,-21.33,;22.32,-23.09,;23.12,-21.75,;24.52,-21.18,;22.02,-20.6,;21.92,-18.99,;21.27,-20.27,;24.86,-18.28,;25.77,-19.52,;25.48,-16.87,)| Show InChI InChI=1S/C39H51N5O6/c1-23(2)29-21-26(37(46)43(5)15-9-14-42(3)4)12-13-31(29)44-32(35-33(49-6)10-8-11-34(35)50-7)22-30(41-44)36(45)40-39(38(47)48)27-17-24-16-25(19-27)20-28(39)18-24/h8,10-13,21-25,27-28H,9,14-20H2,1-7H3,(H,40,45)(H,47,48)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	0.240	n/a	n/a	n/a	n/a	n/a	n/a
Conrad Prebys Center for Chemical Genomics at Sanford-Burnham Medical Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]-neurotensin from NTR1 in HUVEC after 1 hr by gamma counting analysis				ACS Med Chem Lett 4: 846-851 (2013) Article DOI: 10.1021/ml400176n BindingDB Entry DOI: 10.7270/Q2959JZQ
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 2 (Homo sapiens (Human))	BDBM50314931 (1-(7-methyl-1H-indazole-5-carbonyl)-6'-(1-methyl-1...) Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1cc(ncc1O2)-c1cnn(C)c1 Show InChI InChI=1S/C25H24N6O3/c1-15-7-16(8-17-11-27-29-23(15)17)24(33)31-5-3-25(4-6-31)10-21(32)19-9-20(26-13-22(19)34-25)18-12-28-30(2)14-18/h7-9,11-14H,3-6,10H2,1-2H3,(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human recombinant ACC2 expressed in CHO cells after 1 hr by fluorescence reader				Bioorg Med Chem Lett 20: 2383-8 (2010) Article DOI: 10.1016/j.bmcl.2009.04.091 BindingDB Entry DOI: 10.7270/Q22N52DW
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 2 (Homo sapiens (Human))	BDBM50314932 (6'-methoxy-1-(7-methyl-1H-indazole-5-carbonyl)spir...) Show SMILES COc1cc2C(=O)CC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)Oc2cn1 Show InChI InChI=1S/C22H22N4O4/c1-13-7-14(8-15-11-24-25-20(13)15)21(28)26-5-3-22(4-6-26)10-17(27)16-9-19(29-2)23-12-18(16)30-22/h7-9,11-12H,3-6,10H2,1-2H3,(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.310	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human recombinant ACC2 expressed in CHO cells after 1 hr by fluorescence reader				Bioorg Med Chem Lett 20: 2383-8 (2010) Article DOI: 10.1016/j.bmcl.2009.04.091 BindingDB Entry DOI: 10.7270/Q22N52DW
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 2 (Homo sapiens (Human))	BDBM50314938 (5'-isopropoxy-1-(7-methyl-1H-indazole-5-carbonyl)s...) Show SMILES CC(C)Oc1nccc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC(=O)c12 Show InChI InChI=1S/C24H26N4O4/c1-14(2)31-22-20-18(29)12-24(32-19(20)4-7-25-22)5-8-28(9-6-24)23(30)16-10-15(3)21-17(11-16)13-26-27-21/h4,7,10-11,13-14H,5-6,8-9,12H2,1-3H3,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human recombinant ACC2 expressed in CHO cells after 1 hr by fluorescence reader				Bioorg Med Chem Lett 20: 2383-8 (2010) Article DOI: 10.1016/j.bmcl.2009.04.091 BindingDB Entry DOI: 10.7270/Q22N52DW
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 2 (Homo sapiens (Human))	BDBM50314905 (1'-(7-methyl-1H-indazole-5-carbonyl)-6-(1H-pyrazol...) Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1cc(ccc1O2)-c1cc[nH]n1 Show InChI InChI=1S/C25H23N5O3/c1-15-10-17(11-18-14-27-29-23(15)18)24(32)30-8-5-25(6-9-30)13-21(31)19-12-16(2-3-22(19)33-25)20-4-7-26-28-20/h2-4,7,10-12,14H,5-6,8-9,13H2,1H3,(H,26,28)(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human recombinant ACC2 expressed in CHO cells after 1 hr by fluorescence reader				Bioorg Med Chem Lett 20: 2383-8 (2010) Article DOI: 10.1016/j.bmcl.2009.04.091 BindingDB Entry DOI: 10.7270/Q22N52DW
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 2 (Homo sapiens (Human))	BDBM50314906 (1'-(7-methyl-1H-indazole-5-carbonyl)-6-(1-methyl-1...) Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1cc(ccc1O2)-c1ccn(C)n1 Show InChI InChI=1S/C26H25N5O3/c1-16-11-18(12-19-15-27-28-24(16)19)25(33)31-9-6-26(7-10-31)14-22(32)20-13-17(3-4-23(20)34-26)21-5-8-30(2)29-21/h3-5,8,11-13,15H,6-7,9-10,14H2,1-2H3,(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human recombinant ACC2 expressed in CHO cells after 1 hr by fluorescence reader				Bioorg Med Chem Lett 20: 2383-8 (2010) Article DOI: 10.1016/j.bmcl.2009.04.091 BindingDB Entry DOI: 10.7270/Q22N52DW
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 2 (Homo sapiens (Human))	BDBM50314929 (6-(3,5-dimethylisoxazol-4-yl)-1'-(7-methyl-1H-inda...) Show SMILES Cc1noc(C)c1-c1ccc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC(=O)c2c1 Show InChI InChI=1S/C27H26N4O4/c1-15-10-19(11-20-14-28-29-25(15)20)26(33)31-8-6-27(7-9-31)13-22(32)21-12-18(4-5-23(21)34-27)24-16(2)30-35-17(24)3/h4-5,10-12,14H,6-9,13H2,1-3H3,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.40	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human recombinant ACC2 expressed in CHO cells after 1 hr by fluorescence reader				Bioorg Med Chem Lett 20: 2383-8 (2010) Article DOI: 10.1016/j.bmcl.2009.04.091 BindingDB Entry DOI: 10.7270/Q22N52DW
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 2 (Homo sapiens (Human))	BDBM50314925 (5-methoxy-1'-(7-methyl-1H-indazole-5-carbonyl)spir...) Show SMILES COc1cccc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC(=O)c12 Show InChI InChI=1S/C23H23N3O4/c1-14-10-15(11-16-13-24-25-21(14)16)22(28)26-8-6-23(7-9-26)12-17(27)20-18(29-2)4-3-5-19(20)30-23/h3-5,10-11,13H,6-9,12H2,1-2H3,(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human recombinant ACC2 expressed in CHO cells after 1 hr by fluorescence reader				Bioorg Med Chem Lett 20: 2383-8 (2010) Article DOI: 10.1016/j.bmcl.2009.04.091 BindingDB Entry DOI: 10.7270/Q22N52DW
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 2 (Homo sapiens (Human))	BDBM50365293 (CHEMBL1958374) Show SMILES Cc1nc2c(C)cc(cc2[nH]1)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C(C)(C)C Show InChI InChI=1S/C24H29N5O3/c1-14-10-16(11-17-20(14)26-15(2)25-17)22(31)28-8-6-24(7-9-28)12-18(30)21-19(32-24)13-29(27-21)23(3,4)5/h10-11,13H,6-9,12H2,1-5H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.60	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay				J Med Chem 55: 935-42 (2012) Article DOI: 10.1021/jm201503u BindingDB Entry DOI: 10.7270/Q2CZ37MS
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 2 (Homo sapiens (Human))	BDBM50365279 (CHEMBL1958360) Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C(C)(C)C Show InChI InChI=1S/C23H27N5O3/c1-14-9-15(10-16-12-24-25-19(14)16)21(30)27-7-5-23(6-8-27)11-17(29)20-18(31-23)13-28(26-20)22(2,3)4/h9-10,12-13H,5-8,11H2,1-4H3,(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.90	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay				J Med Chem 55: 935-42 (2012) Article DOI: 10.1021/jm201503u BindingDB Entry DOI: 10.7270/Q2CZ37MS
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 1 (Rattus norvegicus (Rat))	BDBM50365279 (CHEMBL1958360) Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C(C)(C)C Show InChI InChI=1S/C23H27N5O3/c1-14-9-15(10-16-12-24-25-19(14)16)21(30)27-7-5-23(6-8-27)11-17(29)20-18(31-23)13-28(26-20)22(2,3)4/h9-10,12-13H,5-8,11H2,1-4H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...				J Med Chem 55: 935-42 (2012) Article DOI: 10.1021/jm201503u BindingDB Entry DOI: 10.7270/Q2CZ37MS
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 2 (Homo sapiens (Human))	BDBM50365292 (CHEMBL1958373) Show SMILES Cc1cc(cc2[nH]cnc12)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C(C)(C)C Show InChI InChI=1S/C23H27N5O3/c1-14-9-15(10-16-19(14)25-13-24-16)21(30)27-7-5-23(6-8-27)11-17(29)20-18(31-23)12-28(26-20)22(2,3)4/h9-10,12-13H,5-8,11H2,1-4H3,(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.40	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay				J Med Chem 55: 935-42 (2012) Article DOI: 10.1021/jm201503u BindingDB Entry DOI: 10.7270/Q2CZ37MS
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 1 (Rattus norvegicus (Rat))	BDBM50314903 (1'-(7-methyl-1H-indazole-5-carbonyl)-6-(1H-pyrazol...) Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1cc(ccc1O2)-c1cn[nH]c1 Show InChI InChI=1S/C25H23N5O3/c1-15-8-17(9-18-12-28-29-23(15)18)24(32)30-6-4-25(5-7-30)11-21(31)20-10-16(2-3-22(20)33-25)19-13-26-27-14-19/h2-3,8-10,12-14H,4-7,11H2,1H3,(H,26,27)(H,28,29)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.40	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter				Bioorg Med Chem Lett 20: 2383-8 (2010) Article DOI: 10.1016/j.bmcl.2009.04.091 BindingDB Entry DOI: 10.7270/Q22N52DW
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 1 (Rattus norvegicus (Rat))	BDBM50314904 (1'-(7-methyl-1H-indazole-5-carbonyl)-6-(1-methyl-1...) Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1cc(ccc1O2)-c1cnn(C)c1 Show InChI InChI=1S/C26H25N5O3/c1-16-9-18(10-19-13-27-29-24(16)19)25(33)31-7-5-26(6-8-31)12-22(32)21-11-17(3-4-23(21)34-26)20-14-28-30(2)15-20/h3-4,9-11,13-15H,5-8,12H2,1-2H3,(H,27,29)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter				Bioorg Med Chem Lett 20: 2383-8 (2010) Article DOI: 10.1016/j.bmcl.2009.04.091 BindingDB Entry DOI: 10.7270/Q22N52DW
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 2 (Homo sapiens (Human))	BDBM50314907 (1'-(7-methyl-1H-indazole-5-carbonyl)-6-(5-methyl-1...) Show SMILES Cc1cc(n[nH]1)-c1ccc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC(=O)c2c1 Show InChI InChI=1S/C26H25N5O3/c1-15-9-18(11-19-14-27-30-24(15)19)25(33)31-7-5-26(6-8-31)13-22(32)20-12-17(3-4-23(20)34-26)21-10-16(2)28-29-21/h3-4,9-12,14H,5-8,13H2,1-2H3,(H,27,30)(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human recombinant ACC2 expressed in CHO cells after 1 hr by fluorescence reader				Bioorg Med Chem Lett 20: 2383-8 (2010) Article DOI: 10.1016/j.bmcl.2009.04.091 BindingDB Entry DOI: 10.7270/Q22N52DW
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM50355142 (CHEMBL1835919) Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(O)=O)CC3)C(=O)c12 |r,wU:16.16,wD:19.20,(-8.41,-1.48,;-8.4,-3.02,;-9.73,-3.79,;-9.73,-5.34,;-8.4,-6.11,;-7.06,-5.34,;-5.73,-6.38,;-4.15,-6.01,;-3.48,-4.52,;-4.27,-3.04,;-3.51,-1.7,;-1.98,-1.68,;-1.22,-.34,;-2.01,.98,;-3.56,.96,;-4.3,-.39,;-1.26,2.32,;-2.05,3.64,;-1.29,4.98,;.25,5,;1.01,6.34,;2.55,6.36,;3.33,5.03,;3.3,7.7,;1.03,3.67,;.28,2.34,;-5.83,-2.78,;-6.22,-1.29,;-7.07,-3.79,)| Show InChI InChI=1S/C21H24N4O4/c22-19-18-20(24-12-23-19)29-10-9-25(21(18)28)16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-17(26)27/h5-8,12-14H,1-4,9-11H2,(H,26,27)(H2,22,23,24)/t13-,14-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of DGAT1-mediated triglyceride synthesis in human HT-29 cells using [3H]glycerol as substrate after 6 hrs by beta counting				ACS Med Chem Lett 2: 407-412 (2011) Article DOI: 10.1021/ml200051p BindingDB Entry DOI: 10.7270/Q2MW2HM6
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 1 (Rattus norvegicus (Rat))	BDBM50365287 (CHEMBL1958368) Show SMILES CCn1nc2c(OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]cc(C)c4c3)CC2=O)c1C Show InChI InChI=1S/C24H28N4O3/c1-5-28-16(4)22-21(26-28)19(29)12-24(31-22)6-8-27(9-7-24)23(30)17-10-14(2)20-18(11-17)15(3)13-25-20/h10-11,13,25H,5-9,12H2,1-4H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...				J Med Chem 55: 935-42 (2012) Article DOI: 10.1021/jm201503u BindingDB Entry DOI: 10.7270/Q2CZ37MS
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 2 (Homo sapiens (Human))	BDBM50365277 (CHEMBL1958359) Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C1CCCC1 Show InChI InChI=1S/C24H27N5O3/c1-15-10-16(11-17-13-25-26-21(15)17)23(31)28-8-6-24(7-9-28)12-19(30)22-20(32-24)14-29(27-22)18-4-2-3-5-18/h10-11,13-14,18H,2-9,12H2,1H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.40	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay				J Med Chem 55: 935-42 (2012) Article DOI: 10.1021/jm201503u BindingDB Entry DOI: 10.7270/Q2CZ37MS
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 1 (Rattus norvegicus (Rat))	BDBM50365292 (CHEMBL1958373) Show SMILES Cc1cc(cc2[nH]cnc12)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C(C)(C)C Show InChI InChI=1S/C23H27N5O3/c1-14-9-15(10-16-19(14)25-13-24-16)21(30)27-7-5-23(6-8-27)11-17(29)20-18(31-23)12-28(26-20)22(2,3)4/h9-10,12-13H,5-8,11H2,1-4H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.60	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...				J Med Chem 55: 935-42 (2012) Article DOI: 10.1021/jm201503u BindingDB Entry DOI: 10.7270/Q2CZ37MS
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 1 (Rattus norvegicus (Rat))	BDBM50365293 (CHEMBL1958374) Show SMILES Cc1nc2c(C)cc(cc2[nH]1)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C(C)(C)C Show InChI InChI=1S/C24H29N5O3/c1-14-10-16(11-17-20(14)26-15(2)25-17)22(31)28-8-6-24(7-9-28)12-18(30)21-19(32-24)13-29(27-21)23(3,4)5/h10-11,13H,6-9,12H2,1-5H3,(H,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...				J Med Chem 55: 935-42 (2012) Article DOI: 10.1021/jm201503u BindingDB Entry DOI: 10.7270/Q2CZ37MS
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 2 (Homo sapiens (Human))	BDBM50314894 (5-(5-methoxy-4-oxospiro[chroman-2,4'-piperidine]-1...) Show SMILES CNC(=O)c1cc2cc(ccc2[nH]1)C(=O)N1CCC2(CC1)CC(=O)c1c(OC)cccc1O2 Show InChI InChI=1S/C25H25N3O5/c1-26-23(30)18-13-16-12-15(6-7-17(16)27-18)24(31)28-10-8-25(9-11-28)14-19(29)22-20(32-2)4-3-5-21(22)33-25/h3-7,12-13,27H,8-11,14H2,1-2H3,(H,26,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human recombinant ACC2 expressed in CHO cells after 1 hr by fluorescence reader				Bioorg Med Chem Lett 20: 2383-8 (2010) Article DOI: 10.1016/j.bmcl.2009.04.091 BindingDB Entry DOI: 10.7270/Q22N52DW
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 2 (Homo sapiens (Human))	BDBM50365295 (CHEMBL1955896) Show SMILES CC(C)(C)n1cc2OC3(CCN(CC3)C(=O)c3ccc4nc[nH]c4c3)CC(=O)c2n1 Show InChI InChI=1S/C22H25N5O3/c1-21(2,3)27-12-18-19(25-27)17(28)11-22(30-18)6-8-26(9-7-22)20(29)14-4-5-15-16(10-14)24-13-23-15/h4-5,10,12-13H,6-9,11H2,1-3H3,(H,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay				J Med Chem 55: 935-42 (2012) Article DOI: 10.1021/jm201503u BindingDB Entry DOI: 10.7270/Q2CZ37MS
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 2 (Homo sapiens (Human))	BDBM50314888 (1'-(3,7-dimethyl-1H-indazole-5-carbonyl)-5-methoxy...) Show SMILES COc1cccc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]nc(C)c4c3)CC(=O)c12 Show InChI InChI=1S/C24H25N3O4/c1-14-11-16(12-17-15(2)25-26-22(14)17)23(29)27-9-7-24(8-10-27)13-18(28)21-19(30-3)5-4-6-20(21)31-24/h4-6,11-12H,7-10,13H2,1-3H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human recombinant ACC2 expressed in CHO cells after 1 hr by fluorescence reader				Bioorg Med Chem Lett 20: 2383-8 (2010) Article DOI: 10.1016/j.bmcl.2009.04.091 BindingDB Entry DOI: 10.7270/Q22N52DW
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 1 (Rattus norvegicus (Rat))	BDBM50365284 (CHEMBL1958365) Show SMILES CCOc1cc(cc2c(C)n[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(CC)c(C)c1O2 Show InChI InChI=1S/C24H29N5O4/c1-5-29-15(4)22-21(27-29)18(30)13-24(33-22)7-9-28(10-8-24)23(31)16-11-17-14(3)25-26-20(17)19(12-16)32-6-2/h11-12H,5-10,13H2,1-4H3,(H,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...				J Med Chem 55: 935-42 (2012) Article DOI: 10.1021/jm201503u BindingDB Entry DOI: 10.7270/Q2CZ37MS
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 1 (Rattus norvegicus (Rat))	BDBM50314943 (1-(3,7-dimethyl-1H-indazole-5-carbonyl)-5'-isoprop...) Show SMILES CC(C)Oc1nccc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]nc(C)c4c3)CC(=O)c12 Show InChI InChI=1S/C25H28N4O4/c1-14(2)32-23-21-19(30)13-25(33-20(21)5-8-26-23)6-9-29(10-7-25)24(31)17-11-15(3)22-18(12-17)16(4)27-28-22/h5,8,11-12,14H,6-7,9-10,13H2,1-4H3,(H,27,28)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter				Bioorg Med Chem Lett 20: 2383-8 (2010) Article DOI: 10.1016/j.bmcl.2009.04.091 BindingDB Entry DOI: 10.7270/Q22N52DW
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 1 (Rattus norvegicus (Rat))	BDBM50365290 (CHEMBL1958371) Show SMILES CC(C)n1cc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]nc(C)c4c3)CC(=O)c2n1 Show InChI InChI=1S/C23H27N5O3/c1-13(2)28-12-19-21(26-28)18(29)11-23(31-19)5-7-27(8-6-23)22(30)16-9-14(3)20-17(10-16)15(4)24-25-20/h9-10,12-13H,5-8,11H2,1-4H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...				J Med Chem 55: 935-42 (2012) Article DOI: 10.1021/jm201503u BindingDB Entry DOI: 10.7270/Q2CZ37MS
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 2 (Homo sapiens (Human))	BDBM50314897 (5-methoxy-1'-(2-(pyridin-2-yl)-1H-benzo[d]imidazol...) Show SMILES COc1cccc2OC3(CCN(CC3)C(=O)c3ccc4nc([nH]c4c3)-c3ccccn3)CC(=O)c12 Show InChI InChI=1S/C27H24N4O4/c1-34-22-6-4-7-23-24(22)21(32)16-27(35-23)10-13-31(14-11-27)26(33)17-8-9-18-20(15-17)30-25(29-18)19-5-2-3-12-28-19/h2-9,12,15H,10-11,13-14,16H2,1H3,(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human recombinant ACC2 expressed in CHO cells after 1 hr by fluorescence reader				Bioorg Med Chem Lett 20: 2383-8 (2010) Article DOI: 10.1016/j.bmcl.2009.04.091 BindingDB Entry DOI: 10.7270/Q22N52DW
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 1 (Rattus norvegicus (Rat))	BDBM50365281 (CHEMBL1958362) Show SMILES CCn1nc2c(OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]nc(C)c4c3)CC2=O)c1C Show InChI InChI=1S/C23H27N5O3/c1-5-28-15(4)21-20(26-28)18(29)12-23(31-21)6-8-27(9-7-23)22(30)16-10-13(2)19-17(11-16)14(3)24-25-19/h10-11H,5-9,12H2,1-4H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...				J Med Chem 55: 935-42 (2012) Article DOI: 10.1021/jm201503u BindingDB Entry DOI: 10.7270/Q2CZ37MS
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 1 (Rattus norvegicus (Rat))	BDBM50314929 (6-(3,5-dimethylisoxazol-4-yl)-1'-(7-methyl-1H-inda...) Show SMILES Cc1noc(C)c1-c1ccc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC(=O)c2c1 Show InChI InChI=1S/C27H26N4O4/c1-15-10-19(11-20-14-28-29-25(15)20)26(33)31-8-6-27(7-9-31)13-22(32)21-12-18(4-5-23(21)34-27)24-16(2)30-35-17(24)3/h4-5,10-12,14H,6-9,13H2,1-3H3,(H,28,29)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter				Bioorg Med Chem Lett 20: 2383-8 (2010) Article DOI: 10.1016/j.bmcl.2009.04.091 BindingDB Entry DOI: 10.7270/Q22N52DW
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 1 (Rattus norvegicus (Rat))	BDBM50365285 (CHEMBL1958366) Show SMILES CCOc1cc(cc2c(CC)n[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(CC)c(C)c1O2 Show InChI InChI=1S/C25H31N5O4/c1-5-18-17-12-16(13-20(33-7-3)21(17)27-26-18)24(32)29-10-8-25(9-11-29)14-19(31)22-23(34-25)15(4)30(6-2)28-22/h12-13H,5-11,14H2,1-4H3,(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...				J Med Chem 55: 935-42 (2012) Article DOI: 10.1021/jm201503u BindingDB Entry DOI: 10.7270/Q2CZ37MS
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 2 (Homo sapiens (Human))	BDBM50365281 (CHEMBL1958362) Show SMILES CCn1nc2c(OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]nc(C)c4c3)CC2=O)c1C Show InChI InChI=1S/C23H27N5O3/c1-5-28-15(4)21-20(26-28)18(29)12-23(31-21)6-8-27(9-7-23)22(30)16-10-13(2)19-17(11-16)14(3)24-25-19/h10-11H,5-9,12H2,1-4H3,(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay				J Med Chem 55: 935-42 (2012) Article DOI: 10.1021/jm201503u BindingDB Entry DOI: 10.7270/Q2CZ37MS
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 1 (Rattus norvegicus (Rat))	BDBM50365294 (CHEMBL1955895) Show SMILES Cn1ncc2ccc(cc12)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C(C)(C)C Show InChI InChI=1S/C23H27N5O3/c1-22(2,3)28-14-19-20(25-28)18(29)12-23(31-19)7-9-27(10-8-23)21(30)15-5-6-16-13-24-26(4)17(16)11-15/h5-6,11,13-14H,7-10,12H2,1-4H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...				J Med Chem 55: 935-42 (2012) Article DOI: 10.1021/jm201503u BindingDB Entry DOI: 10.7270/Q2CZ37MS
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 1 (Rattus norvegicus (Rat))	BDBM50365277 (CHEMBL1958359) Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C1CCCC1 Show InChI InChI=1S/C24H27N5O3/c1-15-10-16(11-17-13-25-26-21(15)17)23(31)28-8-6-24(7-9-28)12-19(30)22-20(32-24)14-29(27-22)18-4-2-3-5-18/h10-11,13-14,18H,2-9,12H2,1H3,(H,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...				J Med Chem 55: 935-42 (2012) Article DOI: 10.1021/jm201503u BindingDB Entry DOI: 10.7270/Q2CZ37MS
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 2 (Homo sapiens (Human))	BDBM50365276 (CHEMBL1958358) Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C1CCC1 Show InChI InChI=1S/C23H25N5O3/c1-14-9-15(10-16-12-24-25-20(14)16)22(30)27-7-5-23(6-8-27)11-18(29)21-19(31-23)13-28(26-21)17-3-2-4-17/h9-10,12-13,17H,2-8,11H2,1H3,(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay				J Med Chem 55: 935-42 (2012) Article DOI: 10.1021/jm201503u BindingDB Entry DOI: 10.7270/Q2CZ37MS
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 2 (Homo sapiens (Human))	BDBM50365290 (CHEMBL1958371) Show SMILES CC(C)n1cc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]nc(C)c4c3)CC(=O)c2n1 Show InChI InChI=1S/C23H27N5O3/c1-13(2)28-12-19-21(26-28)18(29)11-23(31-19)5-7-27(8-6-23)22(30)16-9-14(3)20-17(10-16)15(4)24-25-20/h9-10,12-13H,5-8,11H2,1-4H3,(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay				J Med Chem 55: 935-42 (2012) Article DOI: 10.1021/jm201503u BindingDB Entry DOI: 10.7270/Q2CZ37MS
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 1 (Rattus norvegicus (Rat))	BDBM50365276 (CHEMBL1958358) Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C1CCC1 Show InChI InChI=1S/C23H25N5O3/c1-14-9-15(10-16-12-24-25-20(14)16)22(30)27-7-5-23(6-8-27)11-18(29)21-19(31-23)13-28(26-21)17-3-2-4-17/h9-10,12-13,17H,2-8,11H2,1H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...				J Med Chem 55: 935-42 (2012) Article DOI: 10.1021/jm201503u BindingDB Entry DOI: 10.7270/Q2CZ37MS
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 2 (Homo sapiens (Human))	BDBM50314896 (5-methoxy-1'-(2-phenyl-1H-benzo[d]imidazole-5-carb...) Show SMILES COc1cccc2OC3(CCN(CC3)C(=O)c3ccc4nc([nH]c4c3)-c3ccccc3)CC(=O)c12 Show InChI InChI=1S/C28H25N3O4/c1-34-23-8-5-9-24-25(23)22(32)17-28(35-24)12-14-31(15-13-28)27(33)19-10-11-20-21(16-19)30-26(29-20)18-6-3-2-4-7-18/h2-11,16H,12-15,17H2,1H3,(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human recombinant ACC2 expressed in CHO cells after 1 hr by fluorescence reader				Bioorg Med Chem Lett 20: 2383-8 (2010) Article DOI: 10.1016/j.bmcl.2009.04.091 BindingDB Entry DOI: 10.7270/Q22N52DW
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 2 (Homo sapiens (Human))	BDBM50314895 (5-(5-methoxy-4-oxospiro[chroman-2,4'-piperidine]-1...) Show SMILES COc1cccc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]c(cc4c3)C(N)=O)CC(=O)c12 Show InChI InChI=1S/C25H25N3O5/c1-14-10-16(11-15-12-17(23(26)30)27-22(14)15)24(31)28-8-6-25(7-9-28)13-18(29)21-19(32-2)4-3-5-20(21)33-25/h3-5,10-12,27H,6-9,13H2,1-2H3,(H2,26,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human recombinant ACC2 expressed in CHO cells after 1 hr by fluorescence reader				Bioorg Med Chem Lett 20: 2383-8 (2010) Article DOI: 10.1016/j.bmcl.2009.04.091 BindingDB Entry DOI: 10.7270/Q22N52DW
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 1 (Rattus norvegicus (Rat))	BDBM50314896 (5-methoxy-1'-(2-phenyl-1H-benzo[d]imidazole-5-carb...) Show SMILES COc1cccc2OC3(CCN(CC3)C(=O)c3ccc4nc([nH]c4c3)-c3ccccc3)CC(=O)c12 Show InChI InChI=1S/C28H25N3O4/c1-34-23-8-5-9-24-25(23)22(32)17-28(35-24)12-14-31(15-13-28)27(33)19-10-11-20-21(16-19)30-26(29-20)18-6-3-2-4-7-18/h2-11,16H,12-15,17H2,1H3,(H,29,30)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter				Bioorg Med Chem Lett 20: 2383-8 (2010) Article DOI: 10.1016/j.bmcl.2009.04.091 BindingDB Entry DOI: 10.7270/Q22N52DW
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 2 (Homo sapiens (Human))	BDBM50314889 (5-(5-methoxy-4-oxospiro[chroman-2,4'-piperidine]-1...) Show SMILES COc1cccc2OC3(CCN(CC3)C(=O)c3ccc4nc([nH]c4c3)C(N)=O)CC(=O)c12 Show InChI InChI=1S/C23H22N4O5/c1-31-17-3-2-4-18-19(17)16(28)12-23(32-18)7-9-27(10-8-23)22(30)13-5-6-14-15(11-13)26-21(25-14)20(24)29/h2-6,11H,7-10,12H2,1H3,(H2,24,29)(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human recombinant ACC2 expressed in CHO cells after 1 hr by fluorescence reader				Bioorg Med Chem Lett 20: 2383-8 (2010) Article DOI: 10.1016/j.bmcl.2009.04.091 BindingDB Entry DOI: 10.7270/Q22N52DW
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM27947 (2-[4-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1...) Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1 |r,wU:19.21,wD:22.25,c:12,(1.74,.99,;.97,2.32,;2.46,2.72,;-.37,1.55,;-1.7,2.32,;-3.03,1.55,;-4.37,2.32,;-4.37,3.86,;-3.03,4.63,;-3.03,6.17,;-1.7,3.86,;-.37,4.63,;.97,3.86,;2.3,4.63,;2.3,6.17,;3.63,6.94,;4.97,6.17,;4.97,4.63,;3.63,3.86,;6.19,6.75,;6.19,8.3,;7.53,9.07,;8.86,8.3,;10.19,9.07,;11.53,8.3,;12.86,9.07,;11.53,6.76,;8.86,6.75,;7.53,5.98,)| Show InChI InChI=1S/C22H26N4O3/c1-22(2)19(26-18-20(23)24-12-25-21(18)29-22)16-9-7-15(8-10-16)14-5-3-13(4-6-14)11-17(27)28/h7-10,12-14H,3-6,11H2,1-2H3,(H,27,28)(H2,23,24,25)/t13-,14-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of DGAT1-mediated triglyceride synthesis in human HT-29 cells using [3H]glycerol as substrate after 6 hrs by beta counting				ACS Med Chem Lett 2: 407-412 (2011) Article DOI: 10.1021/ml200051p BindingDB Entry DOI: 10.7270/Q2MW2HM6
					More data for this Ligand-Target Pair				3D Structure (crystal)
Acetyl-CoA carboxylase 1 (Rattus norvegicus (Rat))	BDBM50365295 (CHEMBL1955896) Show SMILES CC(C)(C)n1cc2OC3(CCN(CC3)C(=O)c3ccc4nc[nH]c4c3)CC(=O)c2n1 Show InChI InChI=1S/C22H25N5O3/c1-21(2,3)27-12-18-19(25-27)17(28)11-22(30-18)6-8-26(9-7-22)20(29)14-4-5-15-16(10-14)24-13-23-15/h4-5,10,12-13H,6-9,11H2,1-3H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...				J Med Chem 55: 935-42 (2012) Article DOI: 10.1021/jm201503u BindingDB Entry DOI: 10.7270/Q2CZ37MS
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 1 (Rattus norvegicus (Rat))	BDBM50314928 (1'-(7-methyl-1H-indazole-5-carbonyl)-6-(2-methylox...) Show SMILES Cc1ncc(o1)-c1ccc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC(=O)c2c1 Show InChI InChI=1S/C26H24N4O4/c1-15-9-18(10-19-13-28-29-24(15)19)25(32)30-7-5-26(6-8-30)12-21(31)20-11-17(3-4-22(20)34-26)23-14-27-16(2)33-23/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,28,29)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter				Bioorg Med Chem Lett 20: 2383-8 (2010) Article DOI: 10.1016/j.bmcl.2009.04.091 BindingDB Entry DOI: 10.7270/Q22N52DW
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 1 (Rattus norvegicus (Rat))	BDBM50314886 (1'-(7-ethyl-1H-indazole-5-carbonyl)-6,7-dimethylsp...) Show SMILES CCc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1cc(C)c(C)cc1O2 Show InChI InChI=1S/C25H27N3O3/c1-4-17-11-18(12-19-14-26-27-23(17)19)24(30)28-7-5-25(6-8-28)13-21(29)20-9-15(2)16(3)10-22(20)31-25/h9-12,14H,4-8,13H2,1-3H3,(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter				Bioorg Med Chem Lett 20: 2383-8 (2010) Article DOI: 10.1016/j.bmcl.2009.04.091 BindingDB Entry DOI: 10.7270/Q22N52DW
					More data for this Ligand-Target Pair
Acetyl-CoA carboxylase 1 (Rattus norvegicus (Rat))	BDBM50314905 (1'-(7-methyl-1H-indazole-5-carbonyl)-6-(1H-pyrazol...) Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1cc(ccc1O2)-c1cc[nH]n1 Show InChI InChI=1S/C25H23N5O3/c1-15-10-17(11-18-14-27-29-23(15)18)24(32)30-8-5-25(6-9-30)13-21(31)19-12-16(2-3-22(19)33-25)20-4-7-26-28-20/h2-4,7,10-12,14H,5-6,8-9,13H2,1H3,(H,26,28)(H,27,29)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter				Bioorg Med Chem Lett 20: 2383-8 (2010) Article DOI: 10.1016/j.bmcl.2009.04.091 BindingDB Entry DOI: 10.7270/Q22N52DW
					More data for this Ligand-Target Pair

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