| Reaction Details |
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 | Report a problem with these data |
| Target | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' |
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| Ligand | BDBM50540044 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1980011 (CHEMBL4613146) |
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| IC50 | >10000±n/a nM |
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| Citation |  Wu, Y; Tian, YJ; Le, ML; Zhang, SR; Zhang, C; Huang, MX; Jiang, MY; Zhang, B; Luo, HB Discovery of Novel Selective and Orally Bioavailable Phosphodiesterase-1 Inhibitors for the Efficient Treatment of Idiopathic Pulmonary Fibrosis. J Med Chem63:7867-7879 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' |
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| Name: | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE6C | PDE6C_HUMAN | PDEA2 | Phosphodiesterase 6C | Phosphodiesterase 6C (PDE6C) |
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| Type: | Protein |
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| Mol. Mass.: | 99132.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51160 |
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| Residue: | 858 |
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| Sequence: | MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESA
LCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPT
SKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLL
ATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRS
QILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGE
VEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICN
MMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEY
ITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVD
VIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKV
PVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAF
CHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFET
VIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMT
ACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFI
DFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKA
AEDSGGGDDKKSKTCLML
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| BDBM50540044 |
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| n/a |
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| Name | BDBM50540044 |
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| Synonyms: | CHEMBL4644729 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H25ClFN5O |
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| Mol. Mass. | 453.94 |
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| SMILES | C[C@@H](Nc1nc2n(ncc2c(=O)n1Cc1ccc(F)cc1)C(C)(C)C)c1ccc(Cl)cc1 |r| |
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| Structure | 
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