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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | NAD-dependent protein deacetylase sirtuin-1 | ||
| Ligand | BDBM50193048 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1980070 (CHEMBL4613332) | ||
| EC50 | <1000±n/a nM | ||
| Citation |  Wang, Y; He, J; Liao, M; Hu, M; Li, W; Ouyang, H; Wang, X; Ye, T; Zhang, Y; Ouyang, L An overview of Sirtuins as potential therapeutic target: Structure, function and modulators. Eur J Med Chem161:48-77 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| NAD-dependent protein deacetylase sirtuin-1 | |||
| Name: | NAD-dependent protein deacetylase sirtuin-1 | ||
| Synonyms: | NAD-Dependent Deacetylase Sirtuin-1 | NAD-dependent deacetylase sirtuin 1 | NAD-dependent protein deacetylase sirtuin-1 (SIRT1) | SIR1_HUMAN | SIR2-like protein 1 | SIR2L1 | SIRT1 | Sirtuin 1 (SIRT1) | Sirtuin-1 (SIRT1) | hSIR2 | ||
| Type: | Developmental protein; hydrolase | ||
| Mol. Mass.: | 81626.66 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 747 | ||
| Sequence: |
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| BDBM50193048 | |||
| n/a | |||
| Name | BDBM50193048 | ||
| Synonyms: | CHEMBL3934191 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H25N5O2 | ||
| Mol. Mass. | 415.4876 | ||
| SMILES | CCc1ccccc1-n1c(N)c(C(=O)NCC2CCCO2)c2nc3ccccc3nc12 |(6.08,-32,;7.15,-33.1,;8.65,-32.73,;9.07,-31.25,;10.57,-30.87,;11.64,-31.98,;11.21,-33.45,;9.72,-33.83,;9.3,-35.31,;10.25,-36.51,;11.79,-36.46,;9.38,-37.79,;9.91,-39.24,;8.93,-40.42,;11.43,-39.5,;12.42,-38.33,;13.94,-38.59,;15.05,-37.51,;16.41,-38.24,;16.14,-39.76,;14.62,-39.97,;7.91,-37.37,;6.59,-38.19,;5.23,-37.46,;3.93,-38.27,;2.58,-37.55,;2.51,-36,;3.82,-35.2,;5.18,-35.92,;6.5,-35.11,;7.85,-35.83,)| | ||
| Structure | 
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