| Reaction Details |
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 | Report a problem with these data |
| Target | NAD-dependent protein deacetylase sirtuin-1 |
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| Ligand | BDBM50540060 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1980070 (CHEMBL4613332) |
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| IC50 | 93±n/a nM |
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| Citation |  Wang, Y; He, J; Liao, M; Hu, M; Li, W; Ouyang, H; Wang, X; Ye, T; Zhang, Y; Ouyang, L An overview of Sirtuins as potential therapeutic target: Structure, function and modulators. Eur J Med Chem161:48-77 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NAD-dependent protein deacetylase sirtuin-1 |
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| Name: | NAD-dependent protein deacetylase sirtuin-1 |
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| Synonyms: | NAD-Dependent Deacetylase Sirtuin-1 | NAD-dependent deacetylase sirtuin 1 | NAD-dependent protein deacetylase sirtuin-1 (SIRT1) | SIR1_HUMAN | SIR2-like protein 1 | SIR2L1 | SIRT1 | Sirtuin 1 (SIRT1) | Sirtuin-1 (SIRT1) | hSIR2 |
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| Type: | Developmental protein; hydrolase |
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| Mol. Mass.: | 81626.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 747 |
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| Sequence: | MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREV
PAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNL
YDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRP
RIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDI
NTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIE
YFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRII
QCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPE
QFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLG
DCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSS
PERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDL
KNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSD
SEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTD
GDDQEAINEAISVKQEVTDMNYPSNKS
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| BDBM50540060 |
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| n/a |
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| Name | BDBM50540060 |
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| Synonyms: | CHEMBL4632578 |
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| Type | Small organic molecule |
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| Emp. Form. | C42H25N5Na6O22S6 |
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| Mol. Mass. | 1281.997 |
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| SMILES | [Na;v0+].[Na;v0+].[Na;v0+].[Na;v0+].[Na;v0+].[Na;v0+].[#7]-c1cc(cc(c1)-[#6](=O)-[#7]-c1cccc(c1)-[#6](=O)-[#7]-c1ccc(c2cc(cc(c12)S([#8-])(=O)=O)S([#8-])(=O)=O)S([#8-])(=O)=O)-[#6](=O)-[#7]-c1cccc(c1)-[#6](=O)-[#7]-c1ccc(c2cc(cc(c12)S([#8-])(=O)=O)S([#8-])(=O)=O)S([#8-])(=O)=O |
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| Structure | 
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