Reaction Details |
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Target | Cathepsin K |
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Ligand | BDBM19798 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_48320 |
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Ki | 140±n/a nM |
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Citation | Fenwick, AE; Garnier, B; Gribble, AD; Ife, RJ; Rawlings, AD; Witherington, J Solid-phase synthesis of cyclic alkoxyketones, inhibitors of the cysteine protease cathepsin K. Bioorg Med Chem Lett11:195-8 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Cathepsin K |
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Name: | Cathepsin K |
Synonyms: | CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X |
Type: | Enzyme |
Mol. Mass.: | 36975.68 |
Organism: | Homo sapiens (Human) |
Description: | P43235 |
Residue: | 329 |
Sequence: | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
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BDBM19798 |
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n/a |
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Name | BDBM19798 |
Synonyms: | 3-amidotetrahydrofuran-4-one, 3 | CHEMBL61805 | benzyl N-[(1S)-3-methyl-1-[(4-oxooxolan-3-yl)carbamoyl]butyl]carbamate |
Type | Small organic molecule |
Emp. Form. | C18H24N2O5 |
Mol. Mass. | 348.3936 |
SMILES | CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NC1COCC1=O |r| |
Structure |
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