| Reaction Details |
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 | Report a problem with these data |
| Target | Monoglyceride lipase |
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| Ligand | BDBM50307083 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1982179 (CHEMBL4615441) |
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| IC50 | 205±n/a nM |
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| Citation |  Zhi, Z; Zhang, W; Yao, J; Shang, Y; Hao, Q; Liu, Z; Ren, Y; Li, J; Zhang, G; Wang, J Discovery of Aryl Formyl Piperidine Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase Inhibitors. J Med Chem63:5783-5796 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Monoglyceride lipase |
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| Name: | Monoglyceride lipase |
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| Synonyms: | HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN |
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| Type: | Hydrolase |
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| Mol. Mass.: | 33264.56 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant MGL (Cayman Chemical, cat# 10008354). |
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| Residue: | 303 |
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| Sequence: | MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEE
LARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLG
HSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPID
SSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADR
LCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTA
SPP
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| BDBM50307083 |
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| n/a |
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| Name | BDBM50307083 |
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| Synonyms: | 4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate | CHEMBL606201 | US11753371, Compound JZL-195 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H23N3O5 |
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| Mol. Mass. | 433.4565 |
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| SMILES | [O-][N+](=O)c1ccc(OC(=O)N2CCN(Cc3cccc(Oc4ccccc4)c3)CC2)cc1 |
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| Structure | 
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