| Reaction Details |
|---|
 | Report a problem with these data |
| Target | ATP-dependent RNA helicase DDX3X |
|---|
| Ligand | BDBM50537056 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1982886 (CHEMBL4616148) |
|---|
| IC50 | 400±n/a nM |
|---|
| Citation |  Brai, A; Boccuto, A; Monti, M; Marchi, S; Vicenti, I; Saladini, F; Trivisani, CI; Pollutri, A; Trombetta, CM; Montomoli, E; Riva, V; Garbelli, A; Nola, EM; Zazzi, M; Maga, G; Dreassi, E; Botta, M Exploring the Implication of DDX3X in DENV Infection: Discovery of the First-in-Class DDX3X Fluorescent Inhibitor. ACS Med Chem Lett11:956-962 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| ATP-dependent RNA helicase DDX3X |
|---|
| Name: | ATP-dependent RNA helicase DDX3X |
|---|
| Synonyms: | DBX | DDX3 | DDX3X | DDX3X_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 73247.61 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_811954 |
|---|
| Residue: | 662 |
|---|
| Sequence: | MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGW
SSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFE
RGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIE
SFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILS
QIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVV
YGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQ
IRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVV
WVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDR
EEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGL
ATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGAR
DYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWW
GN
|
|
|
|---|
| BDBM50537056 |
|---|
| n/a |
|---|
| Name | BDBM50537056 |
|---|
| Synonyms: | CHEMBL4571759 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H19F3N4O2S |
|---|
| Mol. Mass. | 424.44 |
|---|
| SMILES | CCCCc1cn(nn1)-c1cccc(c1)S(=O)(=O)Nc1ccccc1C(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
