Reaction Details |
| Report a problem with these data |
Target | 72 kDa type IV collagenase |
---|
Ligand | BDBM50097234 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_106803 |
---|
IC50 | 6.4±n/a nM |
---|
Citation | Fray, MJ; Burslem, MF; Dickinson, RP Selectivity of inhibition of matrix metalloproteases MMP-3 and MMP-2 by succinyl hydroxamates and their carboxylic acid analogues is dependent on P3' group chirality. Bioorg Med Chem Lett11:567-70 (2001) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
72 kDa type IV collagenase |
---|
Name: | 72 kDa type IV collagenase |
Synonyms: | 72 kDa gelatinase | 72 kDa type IV collagenase precursor | CLG4A | Gelatinase A | Gelatinase A (MMP-2) | MMP2 | MMP2_HUMAN | Matrix metalloproteinase-2 | Matrix metalloproteinase-2 (MMP 2) | Matrix metalloproteinase-2 (MMP2) | Matrix metalloproteinases 2 (MMP-2) | TBE-1 |
Type: | Enzyme |
Mol. Mass.: | 73870.36 |
Organism: | Homo sapiens (Human) |
Description: | P08253 |
Residue: | 660 |
Sequence: | MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGC
PKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWD
KNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGD
GYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFN
GKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGT
SYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKY
ESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL
MAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQ
IRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEY
WIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDP
GFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
|
|
|
BDBM50097234 |
---|
n/a |
---|
Name | BDBM50097234 |
Synonyms: | (R)-3-(((S)-3,3-dimethyl-1-oxo-1-(pyridin-4-ylamino)butan-2-yl)carbamoyl)-6-phenylhexanoic acid | (R)-3-[(S)-2,2-Dimethyl-1-(pyridin-4-ylcarbamoyl)-propylcarbamoyl]-6-phenyl-hexanoic acid | CHEMBL345445 |
Type | Small organic molecule |
Emp. Form. | C24H31N3O4 |
Mol. Mass. | 425.5206 |
SMILES | CC(C)(C)[C@H](NC(=O)[C@H](CCCc1ccccc1)CC(O)=O)C(=O)Nc1ccncc1 |
Structure |
|