| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Substance-P receptor |
|---|
| Ligand | BDBM50097647 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_205876 |
|---|
| Ki | 620±n/a nM |
|---|
| Citation |  Aitken, DJ; Ongeri, S; Vallée-Goyet, D; Gramain, JC; Husson, HP Synthesis, modelling and NK1 antagonist evaluation of a non-rigid cyclopropane-containing analogue of CP-99,994. Bioorg Med Chem Lett11:659-61 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Substance-P receptor |
|---|
| Name: | Substance-P receptor |
|---|
| Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 46254.43 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P25103 |
|---|
| Residue: | 407 |
|---|
| Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
|
|
|
|---|
| BDBM50097647 |
|---|
| n/a |
|---|
| Name | BDBM50097647 |
|---|
| Synonyms: | (3,5-Bis-trifluoromethyl-benzyl)-[1-(methylamino-phenyl-methyl)-cyclopropyl]-amine | CHEMBL158212 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H20F6N2 |
|---|
| Mol. Mass. | 402.3766 |
|---|
| SMILES | CNC(c1ccccc1)C1(CC1)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
