| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Retinoic acid receptor alpha |
|---|
| Ligand | BDBM50099474 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_195315 |
|---|
| IC50 | 31±n/a nM |
|---|
| Citation |  Kikuchi, K; Tagami, K; Hibi, S; Yoshimura, H; Tokuhara, N; Tai, K; Hida, T; Yamauchi, T; Nagai, M Syntheses and evaluation of quinoline derivatives as novel retinoic acid receptor alpha antagonists. Bioorg Med Chem Lett11:1215-8 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Retinoic acid receptor alpha |
|---|
| Name: | Retinoic acid receptor alpha |
|---|
| Synonyms: | NR1B1 | Nuclear receptor subfamily 1 group B member 1 | RAR-alpha | RARA | RARA_HUMAN | Retinoic acid receptor alpha | Retinoic acid receptor alpha/Retinoid X receptor alpha | Retinoid X receptor gamma/retinoic acid receptor alpha | Retinoid receptor |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 50778.87 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1466191 |
|---|
| Residue: | 462 |
|---|
| Sequence: | MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT
IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM
VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTL
TPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTV
EFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA
GFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALK
VYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGL
DTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP
|
|
|
|---|
| BDBM50099474 |
|---|
| n/a |
|---|
| Name | BDBM50099474 |
|---|
| Synonyms: | 4-[5-(8-Isopropyl-4-phenyl-quinolin-2-yl)-1H-pyrrol-2-yl]-benzoic acid | CHEMBL20066 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H24N2O2 |
|---|
| Mol. Mass. | 432.5131 |
|---|
| SMILES | CC(C)c1cccc2c(cc(nc12)-c1ccc([nH]1)-c1ccc(cc1)C(O)=O)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
