| Reaction Details |
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 | Report a problem with these data |
| Target | Estrogen receptor |
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| Ligand | BDBM50099586 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_99805 (CHEMBL710408) |
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| IC50 | 69±n/a nM |
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| Citation |  Miller, CP; Collini, MD; Tran, BD; Harris, HA; Kharode, YP; Marzolf, JT; Moran, RA; Henderson, RA; Bender, RH; Unwalla, RJ; Greenberger, LM; Yardley, JP; Abou-Gharbia, MA; Lyttle, CR; Komm, BS Design, synthesis, and preclinical characterization of novel, highly selective indole estrogens. J Med Chem44:1654-7 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Estrogen receptor |
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| Name: | Estrogen receptor |
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| Synonyms: | ER | ER-alpha | ESR | ESR1 | ESR1_HUMAN | Estradiol receptor | Estrogen receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1 |
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| Type: | Protein |
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| Mol. Mass.: | 66230.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03372 |
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| Residue: | 595 |
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| Sequence: | MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
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|
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| BDBM50099586 |
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| n/a |
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| Name | BDBM50099586 |
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| Synonyms: | 2-(4-Hydroxy-phenyl)-3-methyl-1-(6-pyrrolidin-1-yl-hexyl)-1H-indol-5-ol | CHEMBL46903 | ZK-119010 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H32N2O2 |
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| Mol. Mass. | 392.5338 |
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| SMILES | Cc1c(-c2ccc(O)cc2)n(CCCCCCN2CCCC2)c2ccc(O)cc12 |
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| Structure | 
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