| Reaction Details |
|---|
 | Report a problem with these data |
| Target | UDP-glucuronosyltransferase 1A1 |
|---|
| Ligand | BDBM50068270 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1989561 (CHEMBL4623296) |
|---|
| IC50 | 970±n/a nM |
|---|
| Citation |  Chen, Y; Li, Q; Li, Q; Xing, S; Liu, Y; Liu, Y; Chen, Y; Liu, W; Feng, F; Sun, H p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators. J Med Chem63:10135-10157 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| UDP-glucuronosyltransferase 1A1 |
|---|
| Name: | UDP-glucuronosyltransferase 1A1 |
|---|
| Synonyms: | Bilirubin-specific UDPGT isozyme 1 | GNT1 | UD11_HUMAN | UDP-glucuronosyltransferase 1-1 | UDP-glucuronosyltransferase 1-A | UDP-glucuronosyltransferase 1A1 | UDPGT 1-1 | UGT-1A | UGT1 | UGT1*1 | UGT1-01 | UGT1.1 | UGT1A | UGT1A1 | Uridine-5'-diphosphoglucuronosyltransferase 1A1 | hUG-BR1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 59604.34 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P22309 |
|---|
| Residue: | 533 |
|---|
| Sequence: | MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVL
APDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDS
AMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLE
FEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQR
EVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEH
GIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDL
LGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTS
EDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHD
LTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
|
|
|
|---|
| BDBM50068270 |
|---|
| n/a |
|---|
| Name | BDBM50068270 |
|---|
| Synonyms: | (E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one | (E)-3-[5-(1,1-Dimethyl-allyl)-4-hydroxy-2-methoxy-phenyl]-1-(4-hydroxy-phenyl)-propenone | 3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one | 3-[5-((E)-1,1-Dimethyl-allyl)-4-hydroxy-2-methoxy-phenyl]-1-(4-hydroxy-phenyl)-propenone | CHEMBL139702 | Licochalcone A |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H22O4 |
|---|
| Mol. Mass. | 338.397 |
|---|
| SMILES | COc1cc(O)c(cc1\C=C\C(=O)c1ccc(O)cc1)C(C)(C)C=C |
|---|
| Structure | 
|
|---|
Search and Browse
