Reaction Details |
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Target | Thymidine kinase |
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Ligand | BDBM50101052 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_210611 |
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IC50 | 300±n/a nM |
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Citation | Martin, JA; Lambert, RW; Merrett, JH; Parkes, KE; Thomas, GJ; Baker, SJ; Bushnell, DJ; Cansfield, JE; Dunsdon, SJ; Freeman, AC; Hopkins, RA; Johns, IR; Keech, E; Simmonite, H; Walmsley, A; Wong Kai-In, P; Holland, M Nucleoside analogues as highly potent and selective inhibitors of herpes simplex virus thymidine kinase. Bioorg Med Chem Lett11:1655-8 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Thymidine kinase |
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Name: | Thymidine kinase |
Synonyms: | KITH_HHV1S | TK | Thymidine kinase | UL23 |
Type: | PROTEIN |
Mol. Mass.: | 40883.42 |
Organism: | Human herpesvirus 1 (strain SC16) (HHV-1) (Human herpes simplex virus1) |
Description: | ChEMBL_213 |
Residue: | 376 |
Sequence: | MASYPGHQHASAFDQAARSRGHSNRRTALRPRRQQEATEVRPEQKMPTLLRVYIDGPHGM
GKTTTTQLLVALGSRDDIVYVPEPMTYWRVLGASETIANIYTTQHRLDQGEISAGDAAVV
MTSAQITMGMPYAVTDAVLAPHIGGEAGSSHAPPPALTLIFDRHPIAALLCYPAARYLMG
SMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYG
LLANTVRYLQGGGSWREDWGQLSGTAVPPQGAEPQSNAGPRPHIGDTLFTLFRAPELLAP
NGDLYNVFAWALDVLAKRLRPMHVFILDYDQSPAGCRDALLQLTSGMIQTHVTTPGSIPT
ICDLARTFAREMGEAN
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BDBM50101052 |
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n/a |
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Name | BDBM50101052 |
Synonyms: | CHEMBL44535 | N-[(2R,3S,5R)-5-(5-Ethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl]-2-(2-methoxy-phenyl)-acetamide |
Type | Small organic molecule |
Emp. Form. | C20H25N3O6 |
Mol. Mass. | 403.429 |
SMILES | CCc1cn([C@H]2C[C@H](O)[C@@H](CNC(=O)Cc3ccccc3OC)O2)c(=O)[nH]c1=O |
Structure |
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