| Reaction Details |
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 | Report a problem with these data |
| Target | Protein FosB/Transcription factor JunD |
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| Ligand | BDBM29615 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1991495 (CHEMBL4625230) |
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| IC50 | 13100±n/a nM |
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| Citation |  Li, Y; Liu, Z; Aglyamova, G; Chen, J; Chen, H; Bhandari, M; White, MA; Rudenko, G; Zhou, J Discovery of phenanthridine analogues as novel chemical probes disrupting the binding of DNA to ?FosB homodimers and ?FosB/JunD heterodimers. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein FosB/Transcription factor JunD |
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| Name: | Protein FosB/Transcription factor JunD |
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| Synonyms: | Protein fosB/Transcription factor jun-D |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 1991495 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Protein FosB |
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| Synonyms: | FOSB | FOSB_HUMAN | G0/G1 switch regulatory protein 3 | G0S3 | Protein fosB |
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| Type: | PROTEIN |
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| Mol. Mass.: | 35915.32 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_119914 |
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| Residue: | 338 |
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| Sequence: | MFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQECAGLGEMPGSFVPTVTA
ITTSQDLQWLVQPTLISSMAQSQGQPLASQPPVVDPYDMPGTSYSTPGMSGYSSGGASGS
GGPSTSGTTSGPGPARPARARPRRPREETLTPEEEEKRRVRRERNKLAAAKCRNRRRELT
DRLQAETDQLEEEKAELESEIAELQKEKERLEFVLVAHKPGCKIPYEEGPGPGPLAEVRD
LPGSAPAKEDGFSWLLPPPPPPPLPFQTSQDAPPNLTASLFTHSEVQVLGDPFPVVNPSY
TSSFVLTCPEVSAFAGAQRTSGSDQPSDPLNSPSLLAL
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| Component 2 |
| Name: | Transcription factor JunD |
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| Synonyms: | JUND | JUND_HUMAN | Transcription factor jun-D |
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| Type: | PROTEIN |
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| Mol. Mass.: | 35175.00 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_119874 |
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| Residue: | 347 |
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| Sequence: | METPFYGDEALSGLGGGASGSGGSFASPGRLFPGAPPTAAAGSMMKKDALTLSLSEQVAA
ALKPAAAPPPTPLRADGAPSAAPPDGLLASPDLGLLKLASPELERLIIQSNGLVTTTPTS
SQFLYPKVAASEEQEFAEGFVKALEDLHKQNQLGAGAAAAAAAAAAGGPSGTATGSAPPG
ELAPAAAAPEAPVYANLSSYAGGAGGAGGAATVAFAAEPVPFPPPPPPGALGPPRLAALK
DEPQTVPDVPSFGESPPLSPIDMDTQERIKAERKRLRNRIAASKCRKRKLERISRLEEKV
KTLKSQNTELASTASLLREQVAQLKQKVLSHVNSGCQLLPQHQVPAY
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| BDBM29615 |
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| n/a |
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| Name | BDBM29615 |
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| Synonyms: | 6-methoxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid | MLS000072167 | SMR000009698 | US11584714, Compound 15 | cid_652912 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H15NO3 |
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| Mol. Mass. | 245.2738 |
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| SMILES | COc1cccc2C3C=CCC3C(Nc12)C(O)=O |c:8| |
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| Structure | 
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