| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate carboxypeptidase 2 |
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| Ligand | BDBM50102259 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_71709 (CHEMBL680923) |
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| IC50 | 21.7±n/a nM |
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| Citation |  Kozikowski, AP; Nan, F; Conti, P; Zhang, J; Ramadan, E; Bzdega, T; Wroblewska, B; Neale, JH; Pshenichkin, S; Wroblewski, JT Design of remarkably simple, yet potent urea-based inhibitors of glutamate carboxypeptidase II (NAALADase). J Med Chem44:298-301 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamate carboxypeptidase 2 |
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| Name: | Glutamate carboxypeptidase 2 |
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| Synonyms: | FOLH1_RAT | Folh1 | Glutamate carboxypeptidase II | Naalad1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 84547.28 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_68365 |
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| Residue: | 752 |
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| Sequence: | MWNAQQDSDSAEALGRRQRWFCAGTLVLAFTGTFIIGFLFGWFIKPSNDSTSSVSYPGMK
KAFLQELKAENIKKFLYNFTRTPHLAGTQHNFELAKQIHAQWKEFGLDLVELSDYDVLLS
YPNKTHPNYISIINEDGNEIFKTSLAELSPPGYENISDVVPPYSAFSPQGTPEGDLVYVN
YARTEDFFKLERVMKINCSGKIVIARYGQVFRGNKVKNAQLAGAKGIILYSDPADYFVPG
VKSYPDGWNLPGGGVQRGNVLNLNGAGDPLTPGYPANEYAYRHEFTEAVGLPSIPVHPIG
YDDAQKLLEHMGGSAPPDSSWKGGLKVPYNVGPGFAGNFSKQKVKLHIHSYNKVTRIYNV
IGTLKGAVEPDRYVILGGHRDAWVFGGIDPQSGAAVVHEIVRTFGTLKKKGWRPRRTILF
ASWDAEEFGLLGSTEWAEEHSRLLQERGVAYINADSSIEGNYTLRVDCTPLMHSLVYNLT
KELPSPDEGFEGKSLYDSWKEKSPSTEFIGMPRISKLGSGNDFEVFFQRLGIASGRARYT
KNWKNNKVSSYPLYHSVYETYELVEKFYDPTFKYHLTVAQVRGAMVFELANSIVLPFDCQ
SYAVALKKHAETIYNISMNHPQEMKAYMISFDSLFSAVNNFTDVASKFNQRLQDLDKSNP
ILLRILNDQLMYLERAFIDPLGLPGRPFYRHIIYAPSSHNKYAGESFPGIYDALFDINNK
VDTSKAWREVKRQISIAAFTVQAAAETLREVD
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| BDBM50102259 |
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| n/a |
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| Name | BDBM50102259 |
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| Synonyms: | 2-[(2,4-Dicarboxy-butyl)-hydroxy-phosphinoylmethyl]-pentanedioic acid | CHEMBL103725 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H19O10P |
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| Mol. Mass. | 354.247 |
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| SMILES | OC(=O)CC[C@H](CP(O)(=O)C[C@@H](CCC(O)=O)C(O)=O)C(O)=O |
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| Structure | 
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