| Reaction Details |
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 | Report a problem with these data |
| Target | Intercellular adhesion molecule 1 |
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| Ligand | BDBM50105175 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_89057 (CHEMBL698938) |
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| IC50 | 26±n/a nM |
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| Citation |  Zhu, GD; Arendsen, DL; Gunawardana, IW; Boyd, SA; Stewart, AO; Fry, DG; Cool, BL; Kifle, L; Schaefer, V; Meuth, J; Marsh, KC; Kempf-Grote, AJ; Kilgannon, P; Gallatin, WM; Okasinski, GF Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides. J Med Chem44:3469-87 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Intercellular adhesion molecule 1 |
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| Name: | Intercellular adhesion molecule 1 |
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| Synonyms: | CD_antigen=CD54 | ICAM-1 | ICAM1 | ICAM1_HUMAN | Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2 | Intercellular adhesion molecule 1 | Intercellular adhesion molecule-1 | Major group rhinovirus receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57831.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_826675 |
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| Residue: | 532 |
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| Sequence: | MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGI
ETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAP
LPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRRDHH
GANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLD
GLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQE
TLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKA
TPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQ
AWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSPRYE
IVIITVVAAAVIMGTAGLSTYLYNRQRKIKKYRLQQAQKGTPMKPNTQATPP
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| BDBM50105175 |
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| n/a |
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| Name | BDBM50105175 |
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| Synonyms: | 4-(4-{2-[2-(2-Ethoxy-ethoxy)-ethoxy]-1,1-difluoro-ethyl}-phenoxy)-thieno[2,3-c]pyridine-2-carboxylic acid methylamide | CHEMBL115431 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H26F2N2O5S |
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| Mol. Mass. | 480.525 |
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| SMILES | CCOCCOCCOCC(F)(F)c1ccc(Oc2cncc3sc(cc23)C(=O)NC)cc1 |
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| Structure | 
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