| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin F2-alpha receptor |
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| Ligand | BDBM520770 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2017950 (CHEMBL4671528) |
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| IC50 | 0.530±n/a nM |
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| Citation |  Beck, H; Thaler, T; Meibom, D; Meininghaus, M; Jörißen, H; Dietz, L; Terjung, C; Bairlein, M; von Bühler, CJ; Anlauf, S; Fürstner, C; Stellfeld, T; Schneider, D; Gericke, KM; Buyck, T; Lovis, K; Münster, U; Anlahr, J; Kersten, E; Levilain, G; Marossek, V; Kast, R Potent and Selective Human Prostaglandin F (FP) Receptor Antagonist (BAY-6672) for the Treatment of Idiopathic Pulmonary Fibrosis (IPF). J Med Chem63:11639-11662 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin F2-alpha receptor |
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| Name: | Prostaglandin F2-alpha receptor |
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| Synonyms: | PF2R_HUMAN | PGF receptor | PGF2 alpha receptor | PGF2-alpha receptor | PTGFR | Prostaglandin F | Prostanoid FP receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 40072.29 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43088 |
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| Residue: | 359 |
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| Sequence: | MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQ
KSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGL
CPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQ
ASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQG
RSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILD
PWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST
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| BDBM520770 |
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| n/a |
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| Name | BDBM520770 |
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| Synonyms: | (+/−)-5-[({6-Bromo-2-[3-ethylpiperidin-1-yl]-3-methylquinolin-4-yl}carbonyl)amino]-4-(2-chlorophenyl)pentanoic acid (Diastereomer Mixture) | US11149018, Example 57 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H33BrClN3O3 |
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| Mol. Mass. | 586.948 |
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| SMILES | CCC1CCCN(C1)c1nc2ccc(Br)cc2c(C(=O)NCC(CCC(O)=O)c2ccccc2Cl)c1C |
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| Structure | 
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