Reaction Details |
| Report a problem with these data |
Target | Aldo-keto reductase family 1 member B1 |
---|
Ligand | BDBM50107154 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_32098 (CHEMBL644300) |
---|
IC50 | 9720.0±n/a nM |
---|
Citation | Da Settimo, F; Primofiore, G; Da Settimo, A; La Motta, C; Taliani, S; Simorini, F; Novellino, E; Greco, G; Lavecchia, A; Boldrini, E [1,2,4]Triazino[4,3-a]benzimidazole acetic acid derivatives: a new class of selective aldose reductase inhibitors. J Med Chem44:4359-69 (2001) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Aldo-keto reductase family 1 member B1 |
---|
Name: | Aldo-keto reductase family 1 member B1 |
Synonyms: | ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1 |
Type: | PROTEIN |
Mol. Mass.: | 35797.87 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_1512484 |
Residue: | 316 |
Sequence: | MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQ
EKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGP
DYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKP
AVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAK
YNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCA
LMSCAKHKDYPFHAEV
|
|
|
BDBM50107154 |
---|
n/a |
---|
Name | BDBM50107154 |
Synonyms: | CHEMBL335578 | [2-(Carboxymethyl-hydrazono)-3-(3,4-difluoro-benzyl)-2,3-dihydro-benzoimidazol-1-yl]-oxo-acetic acid |
Type | Small organic molecule |
Emp. Form. | C18H14F2N4O5 |
Mol. Mass. | 404.3244 |
SMILES | OC(=O)CN\N=c1/n(Cc2ccc(F)c(F)c2)c2ccccc2n1C(=O)C(O)=O |
Structure |
|