| Reaction Details |
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 | Report a problem with these data |
| Target | Lanosterol synthase |
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| Ligand | BDBM50019333 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2020021 (CHEMBL4673834) |
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| IC50 | 16000±n/a nM |
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| Citation |  Lerner, C; Jakob-Roetne, R; Buettelmann, B; Ehler, A; Rudolph, M; Rodríguez Sarmiento, RM Design of Potent and Druglike Nonphenolic Inhibitors for Catechol O-Methyltransferase Derived from a Fragment Screening Approach Targeting the S-Adenosyl-l-methionine Pocket. J Med Chem59:10163-10175 (2016) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Lanosterol synthase |
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| Name: | Lanosterol synthase |
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| Synonyms: | LSS_RAT | Lss | Osc |
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| Type: | PROTEIN |
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| Mol. Mass.: | 83302.12 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_12083 |
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| Residue: | 733 |
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| Sequence: | MTEGTCLRRRGGPYKTEPATDLTRWRLHNELGRQRWTYYQAEEDPGREQTGLEAHSLGLD
TTSYFKNLPKAQTAHEGALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHIAHIPL
PAGYREEMVRYLRSVQLPDGGWGLHIEDKSTVFGTALSYVSLRILGIGPDDPDLVRARNI
LHKKGGAVAIPSWGKFWLAVLNVYSWEGINTLFPEMWLLPEWFPAHPSTLWCHCRQVYLP
MSYCYATRLSASEDPLVQSLRQELYVEDYASIDWPAQKNNVCPDDMYTPHSWLLHVVYGL
LNLYERFHSTSLRKWAIQLLYEHVAADDRFTKCISIGPISKTVNMLIRWSVDGPSSPAFQ
EHVSRIKDYLWLGLDGMKMQGTNGSQTWDTSFAVQALLEAGAHRRPEFLPCLQKAHEFLR
LSQVPDNNPDYQKYYRHMHKGGFPFSTLDCGWIVADCTAEALKAVLLLQERCPSITEHVP
RERLYDAVAVLLSMRNSDGGFATYETKRGGYLLELLNPSEVFGDIMIDYTYVECTSAVMQ
ALRHFREYFPDHRATESRETLNQGLDFCRKKQRADGSWEGSWGVCFTYGTWFGLEAFACM
GHIYQNRTACAEVAQACHFLLSRQMADGGWGEDFESCEQRRYVQSAGSQVHSTCWALLGL
MAVRHPDISAQERGIRCLLGKQLPNGDWPQENISGVFNKSCAISYTNYRNIFPIWALGRF
SSLYPDNTLAGHI
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| BDBM50019333 |
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| n/a |
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| Name | BDBM50019333 |
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| Synonyms: | CHEMBL3289432 |
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| Type | Small organic molecule |
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| Emp. Form. | C8H9N3S |
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| Mol. Mass. | 179.242 |
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| SMILES | Cc1nc(C)c(s1)-c1cc[nH]n1 |
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| Structure | 
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