| Reaction Details |
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 | Report a problem with these data |
| Target | Hematopoietic prostaglandin D synthase |
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| Ligand | BDBM50550010 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2026072 (CHEMBL4679885) |
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| IC50 | 320±n/a nM |
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| Citation |  Yokoo, H; Shibata, N; Naganuma, M; Murakami, Y; Fujii, K; Ito, T; Aritake, K; Naito, M; Demizu, Y Development of a Hematopoietic Prostaglandin D Synthase-Degradation Inducer. ACS Med Chem Lett12:236-241 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hematopoietic prostaglandin D synthase |
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| Name: | Hematopoietic prostaglandin D synthase |
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| Synonyms: | GSTS | Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | HPGDS | HPGDS_HUMAN | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | PTGDS2 | Prostaglandin D | Prostaglandin D Synthase |
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| Type: | Enzyme |
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| Mol. Mass.: | 23341.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag. |
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| Residue: | 199 |
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| Sequence: | MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLT
LHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELL
TYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKK
VQAIPAVANWIKRRPQTKL
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| BDBM50550010 |
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| n/a |
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| Name | BDBM50550010 |
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| Synonyms: | CHEMBL4762935 |
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| Type | Small organic molecule |
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| Emp. Form. | C53H63N9O13 |
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| Mol. Mass. | 1034.1198 |
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| SMILES | O=C(CCOCCOCCOCCOCCOCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12)N1CCN(CC1)C(=O)C1CCN(CC1)c1ccc(NC(=O)c2cnc(Oc3ccccc3)nc2)cc1 |
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| Structure | 
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