| Reaction Details |
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 | Report a problem with these data |
| Target | Urokinase-type plasminogen activator |
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| Ligand | BDBM50099921 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_212981 |
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| Ki | 101±n/a nM |
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| Citation |  Rudolph, MJ; Illig, CR; Subasinghe, NL; Wilson, KJ; Hoffman, JB; Randle, T; Green, D; Molloy, CJ; Soll, RM; Lewandowski, F; Zhang, M; Bone, R; Spurlino, JC; Deckman, IC; Manthey, C; Sharp, C; Maguire, D; Grasberger, BL; DesJarlais, RL; Zhou, Z Design and synthesis of 4,5-disubstituted-thiophene-2-amidines as potent urokinase inhibitors. Bioorg Med Chem Lett12:491-5 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Urokinase-type plasminogen activator |
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| Name: | Urokinase-type plasminogen activator |
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| Synonyms: | 3.4.21.73 | PLAU | U-plasminogen activator | UROK_HUMAN | Urokinase | Urokinase-type plasminogen activator (uPA) | Urokinase-type plasminogen activator chain B | Urokinase-type plasminogen activator long chain A | Urokinase-type plasminogen activator short chain A | Urokinase-type plasminogen activator/surface receptor | uPA |
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| Type: | Enzyme |
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| Mol. Mass.: | 48528.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00749 |
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| Residue: | 431 |
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| Sequence: | MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQ
HCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN
YCRNPDNRRRPWCYVQVGLKLLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKII
GGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLG
RSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL
PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKML
CAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR
SHTKEENGLAL
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|
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| BDBM50099921 |
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| n/a |
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| Name | BDBM50099921 |
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| Synonyms: | 5-Methylsulfanyl-4-(4-phenyl-thiazol-2-yl)-thiophene-2-carboxamidine | CHEMBL281899 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H13N3S3 |
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| Mol. Mass. | 331.479 |
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| SMILES | CSc1sc(cc1-c1nc(cs1)-c1ccccc1)C(N)=N |
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| Structure | 
|
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