| Reaction Details |
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 | Report a problem with these data |
| Target | Protein arginine N-methyltransferase 1 |
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| Ligand | BDBM50210461 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2026430 (CHEMBL4680588) |
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| IC50 | 15200±n/a nM |
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| Citation |  Qian, K; Yan, C; Su, H; Dang, T; Zhou, B; Wang, Z; Zhao, X; Ivanov, I; Ho, MC; Zheng, YG Pharmacophore-based screening of diamidine small molecule inhibitors for protein arginine methyltransferases. RSC Med Chem12:95-102 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein arginine N-methyltransferase 1 |
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| Name: | Protein arginine N-methyltransferase 1 |
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| Synonyms: | 2.1.1.319 | ANM1_HUMAN | HMT2 | HRMT1L2 | HRMT1L2 {ECO:0000303|PubMed:11097842 | Histone-arginine N-methyltransferase PRMT1 | IR1B4 | Interferon receptor 1-bound protein 4 | PRMT1 | Protein arginine N-methyltransferase 1 | Protein-arginine N-methyltransferase 1 | Synonyms=HMT2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42451.61 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_100878 |
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| Residue: | 371 |
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| Sequence: | MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHF
GIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECS
SISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYA
RDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVV
DPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTG
FSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLC
ELSCSTDYRMR
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| BDBM50210461 |
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| n/a |
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| Name | BDBM50210461 |
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| Synonyms: | (stilbamidine)4-[2-[4-amino(imino)methylphenyl]-(E)-1-ethenyl]phenyl-iminomethanamine | 4,4'-(ethene-1,2-diyl)dibenzimidamide | 4-((E)-2-{4-[(Z)-amino(imino)methyl]phenyl}vinyl)benzenecarboximidamide | 4-((E)-2-{4-[(Z)-amino(imino)methyl]phenyl}vinyl)benzenecarboximidamide(stilbamidine isethionate) | CHEMBL142304 | NSC-35605 | stilbamidine |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16N4 |
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| Mol. Mass. | 264.325 |
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| SMILES | NC(=N)c1ccc(\C=C\c2ccc(cc2)C(N)=N)cc1 |
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| Structure | 
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