| Reaction Details |
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 | Report a problem with these data |
| Target | Protein arginine N-methyltransferase 5 |
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| Ligand | BDBM176872 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2026543 (CHEMBL4680701) |
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| IC50 | 13±n/a nM |
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| Citation |  Duncan, KW; Rioux, N; Boriack-Sjodin, PA; Munchhof, MJ; Reiter, LA; Majer, CR; Jin, L; Johnston, LD; Chan-Penebre, E; Kuplast, KG; Porter Scott, M; Pollock, RM; Waters, NJ; Smith, JJ; Moyer, MP; Copeland, RA; Chesworth, R Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666. ACS Med Chem Lett7:162-6 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein arginine N-methyltransferase 5 |
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| Name: | Protein arginine N-methyltransferase 5 |
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| Synonyms: | 72 kDa ICln-binding protein | ANM5_HUMAN | HRMT1L5 | Histone-arginine N-methyltransferase PRMT5 | IBP72 | JBP1 | Jak-binding protein 1 | PRMT5 | PRMT5/MEP50 complex | Protein arginine N-methyltransferase 5 (PRMT5) | Protein arginine methyltransferase 5 (PRMT5) | SKB1 | SKB1 homolog | SKB1Hs | Shk1 kinase-binding protein 1 homolog |
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| Type: | Enzyme |
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| Mol. Mass.: | 72679.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O14744 |
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| Residue: | 637 |
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| Sequence: | MAAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVAKQGFDFLCMPVFHPRFKREFIQEPAK
NRPGPQTRSDLLLSGRDWNTLIVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGAYLGLP
AFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYS
GEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNK
KGFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELF
AKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQV
LMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDM
REWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKL
YNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEF
PVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICV
RFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL
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| BDBM176872 |
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| n/a |
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| Name | BDBM176872 |
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| Synonyms: | US10307413, Compound 44 | US10391089, Compound 44 | US10980794, Cmpd No 44 | US9675614, 44 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H31N3O3 |
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| Mol. Mass. | 409.5212 |
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| SMILES | O[C@@H](CNC(=O)c1cccc(NC2CCOCC2)c1)CN1CCc2ccccc2C1 |r| |
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| Structure | 
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