| Reaction Details |
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 | Report a problem with these data |
| Target | Sigma non-opioid intracellular receptor 1 |
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| Ligand | BDBM50551236 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2031061 (CHEMBL4685219) |
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| Ki | 17±n/a nM |
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| Citation |  Temme, L; Bechthold, E; Schreiber, JA; Gawaskar, S; Schepmann, D; Robaa, D; Sippl, W; Seebohm, G; Wünsch, B Negative allosteric modulators of the GluN2B NMDA receptor with phenylethylamine structure embedded in ring-expanded and ring-contracted scaffolds. Eur J Med Chem190:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sigma non-opioid intracellular receptor 1 |
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| Name: | Sigma non-opioid intracellular receptor 1 |
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| Synonyms: | OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein |
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| Type: | Protein |
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| Mol. Mass.: | 25307.17 |
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| Organism: | Cavia porcellus (Guinea pig) |
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| Description: | Q60492 |
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| Residue: | 223 |
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| Sequence: | MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSK
LIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
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| BDBM50551236 |
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| n/a |
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| Name | BDBM50551236 |
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| Synonyms: | CHEMBL4754021 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H25N |
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| Mol. Mass. | 279.4192 |
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| SMILES | C(CN1CCCc2ccccc2CC1)Cc1ccccc1 |
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| Structure | 
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