| Reaction Details |
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 | Report a problem with these data |
| Target | Serine protease 1 |
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| Ligand | BDBM50111714 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_212857 |
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| Ki | 12±n/a nM |
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| Citation |  Reiner, JE; Siev, DV; Araldi, GL; Cui, JJ; Ho, JZ; Reddy, KM; Mamedova, L; Vu, PH; Lee, KS; Minami, NK; Gibson, TS; Anderson, SM; Bradbury, AE; Nolan, TG; Semple, JE Non-covalent thrombin inhibitors featuring P(3)-heterocycles with P(1)-monocyclic arginine surrogates. Bioorg Med Chem Lett12:1203-8 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine protease 1 |
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| Name: | Serine protease 1 |
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| Synonyms: | Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 26557.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07477 |
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| Residue: | 247 |
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| Sequence: | MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS
AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN
ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT
SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK
NTIAANS
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| BDBM50111714 |
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| n/a |
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| Name | BDBM50111714 |
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| Synonyms: | CHEMBL416912 | N-(4-Carbamimidoyl-2-methoxy-benzyl)-2-[3-(3-methoxy-benzenesulfonylamino)-2-oxo-2H-pyridin-1-yl]-acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C23H25N5O6S |
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| Mol. Mass. | 499.54 |
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| SMILES | COc1cccc(c1)S(=O)(=O)Nc1cccn(CC(=O)NCc2ccc(cc2OC)C(N)=N)c1=O |
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| Structure | 
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