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TargetThrombin and coagulation factor X
LigandBDBM50111718
Substrate/Competitorn/a
Meas. Tech.ChEBML_208494
Ki 6±n/a nM
Citation Reiner JESiev DVAraldi GLCui JJHo JZReddy KMMamedova LVu PHLee KSMinami NKGibson TSAnderson SMBradbury AENolan TGSemple JE Non-covalent thrombin inhibitors featuring P(3)-heterocycles with P(1)-monocyclic arginine surrogates. Bioorg Med Chem Lett 12:1203-8 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Thrombin and coagulation factor X
Name:Thrombin and coagulation factor X
Synonyms:Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin | Prothrombin precursor | Thrombin heavy chain | Thrombin light chain
Type:Protein
Mol. Mass.:70029.57
Organism:Homo sapiens (Human)
Description:P00734
Residue:622
Sequence:
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
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  Blast E-value cutoff:
BDBM50111718
n/a
NameBDBM50111718
Synonyms:CHEMBL279199 | N-(4-Carbamimidoyl-2-fluoro-benzyl)-2-[3-(3-methoxy-benzenesulfonylamino)-2-oxo-2H-pyridin-1-yl]-acetamide
TypeSmall organic molecule
Emp. Form.C22H22FN5O5S
Mol. Mass.487.504
SMILESCOc1cccc(c1)S(=O)(=O)Nc1cccn(CC(=O)NCc2ccc(cc2F)C(N)=N)c1=O
Structure
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