| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM50552765 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2035378 (CHEMBL4689536) |
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| IC50 | 1.1±n/a nM |
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| Citation |  Dykstra, KD; Streckfuss, E; Liu, M; Liu, J; Yu, Y; Wang, M; Kozlowski, JA; Myers, RW; Buevich, AV; Maletic, MM; Vachal, P; Krska, SW Synthesis of HDAC Inhibitor Libraries via Microscale Workflow. ACS Med Chem Lett12:337-342 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM50552765 |
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| n/a |
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| Name | BDBM50552765 |
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| Synonyms: | CHEMBL4758559 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H46N4O6 |
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| Mol. Mass. | 606.7522 |
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| SMILES | CCOC(=O)c1cc2cc(OC)c(cc2o1)-c1cnc([nH]1)[C@H](CCCCCC(=O)CC)NC(=O)[C@H]1CC11CCN(CC)CC1 |r| |
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| Structure | 
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