| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neuropeptides B/W receptor type 1 |
|---|
| Ligand | BDBM50553729 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2047119 (CHEMBL4701818) |
|---|
| IC50 | 53±n/a nM |
|---|
| Citation |  Moningka, R; Romero, FA; Hastings, NB; Guo, Z; Wang, M; Di Salvo, J; Li, Y; Trusca, D; Deng, Q; Tong, V; Terebetski, JL; Ball, RG; Ujjainwalla, F Fragment-based lead discovery of a novel class of small molecule antagonists of neuropeptide B/W receptor subtype 1 (GPR7). Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neuropeptides B/W receptor type 1 |
|---|
| Name: | Neuropeptides B/W receptor type 1 |
|---|
| Synonyms: | GPR7 | NPBW1_HUMAN | NPBWR1 | neuropeptides B/W receptor 1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 36111.82 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_119607128 |
|---|
| Residue: | 328 |
|---|
| Sequence: | MDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLY
VLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNT
FSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLD
DEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAK
ALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANS
CLNPFLYAFLDASFRRNLRQLITCRAAA
|
|
|
|---|
| BDBM50553729 |
|---|
| n/a |
|---|
| Name | BDBM50553729 |
|---|
| Synonyms: | CHEMBL4796786 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H11Cl2F3N4 |
|---|
| Mol. Mass. | 423.219 |
|---|
| SMILES | Nc1ccc(cn1)-c1cc(Cl)c(-c2nc3cc(ccc3[nH]2)C(F)(F)F)c(Cl)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
