| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-K receptor |
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| Ligand | BDBM50115970 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_209019 (CHEMBL815540) |
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| IC50 | 30±n/a nM |
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| Citation |  Mah, R; Gerspacher, M; von Sprecher, A; Stutz, S; Tschinke, V; Anderson, GP; Bertrand, C; Subramanian, N; Ball, HA Biphenyl derivatives as novel dual NK(1)/NK(2)-receptor antagonists. Bioorg Med Chem Lett12:2065-8 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-K receptor |
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| Name: | Substance-K receptor |
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| Synonyms: | NK-2 receptor | NK-2R | NK2R | NK2R_HUMAN | NKNAR | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | Neurokinin-2 (NK-2) | Neuromedin-2 receptor (NK-2R) | SKR | TAC2R | TACR2 | Tachykinin receptor 2 | Tachykinin receptor 2 (NK2) | hnk-3 |
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| Type: | Protein |
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| Mol. Mass.: | 44455.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21452 |
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| Residue: | 398 |
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| Sequence: | MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILA
HRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVS
IYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATK
CVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLR
HLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSST
MYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMA
GDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
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| BDBM50115970 |
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| n/a |
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| Name | BDBM50115970 |
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| Synonyms: | 4'-Chloro-2-(3,4,5-trimethoxy-benzoylamino)-biphenyl-4-carboxylic acid cyclohexylamide | CHEMBL62341 | N-[4'-Chloro-4-(2-cyclohexylamino-acetyl)-biphenyl-2-yl]-3,4,5-trimethoxy-benzamide |
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| Type | Small organic molecule |
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| Emp. Form. | C29H31ClN2O5 |
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| Mol. Mass. | 523.02 |
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| SMILES | COc1cc(cc(OC)c1OC)C(=O)Nc1cc(ccc1-c1ccc(Cl)cc1)C(=O)NC1CCCCC1 |
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| Structure | 
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