| Reaction Details |
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 | Report a problem with these data |
| Target | Folylpolyglutamate synthase, mitochondrial |
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| Ligand | BDBM50116251 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_68690 |
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| IC50 | 8600±n/a nM |
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| Citation |  Tsukamoto, T; Flanary, JM; Rojas, C; Slusher, BS; Valiaeva, N; Coward, JK Phosphonate and phosphinate analogues of N-acylated gamma-glutamylglutamate. potent inhibitors of glutamate carboxypeptidase II. Bioorg Med Chem Lett12:2189-92 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Folylpolyglutamate synthase, mitochondrial |
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| Name: | Folylpolyglutamate synthase, mitochondrial |
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| Synonyms: | FOLC_HUMAN | FPGS | Folylpoly-gamma-glutamate synthetase | Folylpolyglutamate synthase, mitochondrial | Tetrahydrofolate synthase | Tetrahydrofolylpolyglutamate synthase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 64621.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_68676 |
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| Residue: | 587 |
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| Sequence: | MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAG
YLEQVKRQRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVTGTKGKGSTCAFTECILRS
YGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHRLEETKDGSCVSMPPYFRF
LTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIA
WQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCPMLEALEEGGPPLTLGLEGE
HQRSNAALALQLAHCWLQRQDRHGAGEPKASRPGLLWQLPLAPVFQPTSHMRLGLRNTEW
PGRTQVLRRGPLTWYLDGAHTASSAQACVRWFRQALQGRERPSGGPEVRVLLFNATGDRD
PAALLKLLQPCQFDYAVFCPNLTEVSSTGNADQQNFTVTLDQVLLRCLEHQQHWNHLDEE
QASPDLWSAPSPEPGGSASLLLAPHPPHTCSASSLVFSCISHALQWISQGRDPIFQPPSP
PKGLLTHPVAHSGASILREAAAIHVLVTGSLHLVGGVLKLLEPALSQ
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| BDBM50116251 |
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| n/a |
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| Name | BDBM50116251 |
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| Synonyms: | 2-{[3-(4-Amino-benzoylamino)-3-carboxy-propyl]-hydroxy-phosphinoyloxy}-pentanedioic acid | CHEMBL307085 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H21N2O10P |
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| Mol. Mass. | 432.3191 |
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| SMILES | Nc1ccc(cc1)C(=O)N[C@@H](CCP(O)(=O)O[C@@H](CCC(O)=O)C(O)=O)C(O)=O |
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| Structure | 
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