Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetGranzyme B
LigandBDBM50116261
Substrate/Competitorn/a
Meas. Tech.ChEBML_72172
Ki 75±n/a nM
Citation Willoughby CABull HGGarcia-Calvo MJiang JChapman KTThornberry NA Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis. Bioorg Med Chem Lett 12:2197-200 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Granzyme B
Name:Granzyme B
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:27735.56
Organism:Homo sapiens (Human)
Description:ChEMBL_469245
Residue:247
Sequence:
MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVL
TAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR
TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY
YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWI
KKTMKRY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50116261
n/a
NameBDBM50116261
Synonyms:(2S,5S)-5-((R)-3-Methyl-2-pyridin-2-yl-butyrylamino)-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indole-2-carboxylic acid (1H-[1,2,3]triazol-4-ylmethyl)-amide | CHEMBL304727
TypeSmall organic molecule
Emp. Form.C26H29N7O3
Mol. Mass.487.5536
SMILESCC(C)[C@@H](C(=O)N[C@H]1CCc2cccc3C[C@H](N(c23)C1=O)C(=O)NCc1cnn[nH]1)c1ccccn1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: