| Reaction Details |
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 | Report a problem with these data |
| Target | Coiled-coil domain-containing protein 6 |
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| Ligand | BDBM50556136 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2054991 (CHEMBL4709992) |
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| IC50 | 5.4±n/a nM |
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| Citation |  Li, X; Su, J; Yang, Y; Lian, W; Deng, Z; Yang, Z; Chen, G; Zhang, B; Dong, C; Liu, X; Li, L; Wang, Z; Hu, Z; Xu, Q; Deng, X Discovery of 4-methyl-N-(4-((4-methylpiperazin- 1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-oxy)benzamide as a potent inhibitor of RET and its gatekeeper mutant. Eur J Med Chem207:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coiled-coil domain-containing protein 6 |
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| Name: | Coiled-coil domain-containing protein 6 |
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| Synonyms: | CCDC6 | CCDC6_HUMAN | Coiled-coil domain-containing protein 6 | D10S170 | Papillary thyroid carcinoma-encoded protein | Protein H4 | TST1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53294.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109661 |
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| Residue: | 474 |
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| Sequence: | MADSASESDTDGAGGNSSSSAAMQSSCSSTSGGGGGGGGGGGGGKSGGIVISPFRLEELT
NRLASLQQENKVLKIELETYKLKCKALQEENRDLRKASVTIQARAEQEEEFISNTLFKKI
QALQKEKETLAVNYEKEEEFLTNELSRKLMQLQHEKAELEQHLEQEQEFQVNKLMKKIKK
LENDTISKQLTLEQLRREKIDLENTLEQEQEALVNRLWKRMDKLEAEKRILQEKLDQPVS
APPSPRDISMEIDSPENMMRHIRFLKNEVERLKKQLRAAQLQHSEKMAQYLEEERHMREE
NLRLQRKLQREMERREALCRQLSESESSLEMDDERYFNEMSAQGLRPRTVSSPIPYTPSP
SSSRPISPGLSYASHTVGFTPPTSLTRAGMSYYNSPGLHVQHMGTSHGITRPSPRRSNSP
DKFKRPTPPPSPNTQTPVQPPPPPPPPPMQPTVPSAATSQPTPSQHSAHPSSQP
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| BDBM50556136 |
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| n/a |
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| Name | BDBM50556136 |
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| Synonyms: | CHEMBL4790634 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H29F3N8O2 |
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| Mol. Mass. | 602.6096 |
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| SMILES | CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(Oc4nc(nc5[nH]ncc45)-c4cccnc4)c3)cc2C(F)(F)F)CC1 |
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| Structure | 
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