| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50117897 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_87073 |
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| Ki | 310±n/a nM |
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| Citation |  Ting, P; Lee, J; Albanese, M; Tom, W; Solomon, D; Aslanian, R; Shih, N; West, R The synthesis of substituted fluorenes as novel non-imidazole histamine h(3) inhibitors. Bioorg Med Chem Lett12:2643-6 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48691.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
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| Residue: | 445 |
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| Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
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| BDBM50117897 |
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| n/a |
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| Name | BDBM50117897 |
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| Synonyms: | 2-[2-(1-Methyl-pyrrolidin-2-yl)-ethoxy]-fluoren-9-one oxime | CHEMBL90044 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22N2O2 |
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| Mol. Mass. | 322.4009 |
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| SMILES | CN1CCCC1CCOc1ccc-2c(c1)C(N=O)c1ccccc-21 |
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| Structure | 
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