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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dimer of Protein farnesyltransferase subunit beta | ||
| Ligand | BDBM50117932 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_161567 (CHEMBL768930) | ||
| IC50 | 5.8±n/a nM | ||
| Citation |  Taveras, AG; Aki, C; Chao, J; Doll, RJ; Lalwani, T; Girijavallabhan, V; Strickland, CL; Windsor, WT; Weber, P; Hollinger, F; Snow, M; Patton, R; Kirschmeier, P; James, L; Liu, M; Nomeir, A Exploring the role of bromine at C(10) of (+)-4-[2-[4-(8-chloro-3,10-dibromo- 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(R)-yl)-1-piperidinyl]-2- oxoethyl]-1-piperidinecarboxamide (Sch-66336): the discovery of indolocycloheptapyridine inhibitors of farnesyl protein transferase. J Med Chem45:3854-64 (2002) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dimer of Protein farnesyltransferase subunit beta | |||
| Name: | Dimer of Protein farnesyltransferase subunit beta | ||
| Synonyms: | Protein Farnesyltransferase (PFT) Chain B | ||
| Type: | n/a | ||
| Mol. Mass.: | n/a | ||
| Description: | ASSAY_ID of EBI is 51428 | ||
| Components: | This complex has 3 components. | ||
| Component 1 | |||
| Name: | Protein farnesyltransferase subunit beta | ||
| Synonyms: | CAAX farnesyltransferase subunit alpha | CAAX farnesyltransferase subunit beta | FNTB | FNTB_HUMAN | FTase-alpha | FTase-beta | GGTase-I-alpha | Protein Farnesyltransferase (PFT) Chain B | Protein farnesyl/geranylgeranyl transferase | Protein farnesyltransferase beta subunit | Protein farnesyltransferase subunit beta | Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Ras proteins prenyltransferase subunit alpha | Ras proteins prenyltransferase subunit beta | Type I protein geranyl-geranyltransferase subunit alpha | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 48766.02 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Protein farnesyltransferase subunit beta | ||
| Residue: | 437 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | Protein farnesyltransferase subunit beta | ||
| Synonyms: | CAAX farnesyltransferase subunit alpha | CAAX farnesyltransferase subunit beta | FNTB | FNTB_HUMAN | FTase-alpha | FTase-beta | GGTase-I-alpha | Protein Farnesyltransferase (PFT) Chain B | Protein farnesyl/geranylgeranyl transferase | Protein farnesyltransferase beta subunit | Protein farnesyltransferase subunit beta | Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Ras proteins prenyltransferase subunit alpha | Ras proteins prenyltransferase subunit beta | Type I protein geranyl-geranyltransferase subunit alpha | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 48766.02 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Protein farnesyltransferase subunit beta | ||
| Residue: | 437 | ||
| Sequence: |
| ||
| BDBM50117932 | |||
| n/a | |||
| Name | BDBM50117932 | ||
| Synonyms: | (+/-)4-{2-[4-(9-bromo-4-chloro-1-methyl-3,6,7,12-tetrahydropyrido[2',3':4,5]cyclohepta[e]indol-12-yliden)hexahydro-1-pyridinyl]-2-oxoethyl}-1-pyridiniumolate | CHEMBL338930 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H26BrClN4O2 | ||
| Mol. Mass. | 577.899 | ||
| SMILES | Cc1c[nH]c2c(Cl)cc3CCc4cc(Br)cnc4C(=C4CCN(CC4)C(=O)Cc4cc[n+]([O-])cc4)c3c12 |(13.66,-11.28,;13.26,-9.8,;14.73,-10.3,;15.66,-9.06,;14.77,-7.79,;15.1,-6.28,;16.57,-5.82,;13.96,-5.23,;12.49,-5.69,;11.53,-4.49,;9.99,-4.49,;9.04,-5.7,;7.57,-5.27,;6.45,-6.32,;4.98,-5.88,;6.81,-7.82,;8.27,-8.26,;9.39,-7.21,;10.76,-7.86,;10.76,-9.4,;12.09,-10.18,;12.09,-11.72,;10.76,-12.48,;9.45,-11.72,;9.45,-10.18,;10.76,-14.02,;9.43,-14.79,;12.11,-14.79,;12.11,-16.33,;10.76,-17.1,;10.76,-18.64,;12.09,-19.41,;12.09,-20.95,;13.44,-18.63,;13.42,-17.09,;12.16,-7.19,;13.28,-8.24,)| | ||
| Structure | 
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