| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dimer of Protein farnesyltransferase subunit beta |
|---|
| Ligand | BDBM50117937 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_161567 (CHEMBL768930) |
|---|
| IC50 | 2.6±n/a nM |
|---|
| Citation |  Taveras, AG; Aki, C; Chao, J; Doll, RJ; Lalwani, T; Girijavallabhan, V; Strickland, CL; Windsor, WT; Weber, P; Hollinger, F; Snow, M; Patton, R; Kirschmeier, P; James, L; Liu, M; Nomeir, A Exploring the role of bromine at C(10) of (+)-4-[2-[4-(8-chloro-3,10-dibromo- 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(R)-yl)-1-piperidinyl]-2- oxoethyl]-1-piperidinecarboxamide (Sch-66336): the discovery of indolocycloheptapyridine inhibitors of farnesyl protein transferase. J Med Chem45:3854-64 (2002) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dimer of Protein farnesyltransferase subunit beta |
|---|
| Name: | Dimer of Protein farnesyltransferase subunit beta |
|---|
| Synonyms: | Protein Farnesyltransferase (PFT) Chain B |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of EBI is 51428 |
|---|
| Components: | This complex has 3 components. |
|---|
| Component 1 |
| Name: | Protein farnesyltransferase subunit beta |
|---|
| Synonyms: | CAAX farnesyltransferase subunit alpha | CAAX farnesyltransferase subunit beta | FNTB | FNTB_HUMAN | FTase-alpha | FTase-beta | GGTase-I-alpha | Protein Farnesyltransferase (PFT) Chain B | Protein farnesyl/geranylgeranyl transferase | Protein farnesyltransferase beta subunit | Protein farnesyltransferase subunit beta | Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Ras proteins prenyltransferase subunit alpha | Ras proteins prenyltransferase subunit beta | Type I protein geranyl-geranyltransferase subunit alpha |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 48766.02 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Protein farnesyltransferase subunit beta |
|---|
| Residue: | 437 |
|---|
| Sequence: | MASPSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFS
SYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQ
IVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQY
LYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIG
GVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCY
SFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDF
YHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPV
PGFEELKDETSAEPATD
|
|
|
|---|
| Component 2 |
| Name: | Protein farnesyltransferase subunit beta |
|---|
| Synonyms: | CAAX farnesyltransferase subunit alpha | CAAX farnesyltransferase subunit beta | FNTB | FNTB_HUMAN | FTase-alpha | FTase-beta | GGTase-I-alpha | Protein Farnesyltransferase (PFT) Chain B | Protein farnesyl/geranylgeranyl transferase | Protein farnesyltransferase beta subunit | Protein farnesyltransferase subunit beta | Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Ras proteins prenyltransferase subunit alpha | Ras proteins prenyltransferase subunit beta | Type I protein geranyl-geranyltransferase subunit alpha |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 48766.02 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Protein farnesyltransferase subunit beta |
|---|
| Residue: | 437 |
|---|
| Sequence: | MASPSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFS
SYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQ
IVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQY
LYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIG
GVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCY
SFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDF
YHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPV
PGFEELKDETSAEPATD
|
|
|
|---|
| BDBM50117937 |
|---|
| n/a |
|---|
| Name | BDBM50117937 |
|---|
| Synonyms: | (+)4-(2-{4-[9-bromo-4-chloro-1-methyl-(12R)-3,6,7,12-tetrahydropyrido[2',3':4,5]cyclohepta[e]indol-12-yl]hexahydro-1-pyridinyl}-2-oxoethyl)-1-pyridiniumolate | CHEMBL127697 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H28BrClN4O2 |
|---|
| Mol. Mass. | 579.915 |
|---|
| SMILES | Cc1c[nH]c2c(Cl)cc3CCc4cc(Br)cnc4[C@H](C4CCN(CC4)C(=O)Cc4cc[n+]([O-])cc4)c3c12 |
|---|
| Structure | 
|
|---|
Search and Browse
