| Reaction Details |
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 | Report a problem with these data |
| Target | Fructose-1,6-bisphosphatase 1 |
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| Ligand | BDBM50117955 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_69130 (CHEMBL681254) |
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| IC50 | 520±n/a nM |
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| Citation |  Wright, SW; Carlo, AA; Carty, MD; Danley, DE; Hageman, DL; Karam, GA; Levy, CB; Mansour, MN; Mathiowetz, AM; McClure, LD; Nestor, NB; McPherson, RK; Pandit, J; Pustilnik, LR; Schulte, GK; Soeller, WC; Treadway, JL; Wang, IK; Bauer, PH Anilinoquinazoline inhibitors of fructose 1,6-bisphosphatase bind at a novel allosteric site: synthesis, in vitro characterization, and X-ray crystallography. J Med Chem45:3865-77 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Fructose-1,6-bisphosphatase 1 |
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| Name: | Fructose-1,6-bisphosphatase 1 |
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| Synonyms: | F16P1_RAT | Fbp | Fbp1 | Fructose-1,6-bisphosphatase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 39605.40 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_595158 |
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| Residue: | 363 |
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| Sequence: | MVDHAPFETDISTLTRFVLEEGRKAGGTGEMTQLLNSLCTAIKAISSAVRQAGIAQLYGI
AGSTNVTGDQVKKLDILSNDLVINMLKSSYATCVLVSEEDTHAIIIEPEKRGKYVVCFDP
LDGSSNIDCLASIGTIFGIYRKTSANEPSEKDALQPGRNLVAAGYALYGSATMLVLAMNC
GVNCFMLDPSIGEFILVDRDVKIKKKGNIYSINEGYAKDFDPAINEYIQRKKFPPDNSAP
YGARYVGSMVADVHRTLVYGGIFLYPANKKNPSGKLRLLYECNPIAYVMEKAGGLATTGN
EDILDIVPTEIHQKAPVIMGSTEDVQEFLEIYNKDKAKSRPSLPLPQSRARESPVHSICD
ELF
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| BDBM50117955 |
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| n/a |
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| Name | BDBM50117955 |
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| Synonyms: | 4-[3-(6,7-Diethoxy-quinazolin-4-ylamino)-phenyl]-thiazole-2-carboxylic acid amide | CHEMBL419776 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H21N5O3S |
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| Mol. Mass. | 435.499 |
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| SMILES | CCOc1cc2ncnc(Nc3cccc(c3)-c3csc(n3)C(N)=O)c2cc1OCC |
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| Structure | 
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