Reaction Details |
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Target | Thyroid hormone receptor beta |
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Ligand | BDBM50133531 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2058576 (CHEMBL4713577) |
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Kd | 590±n/a nM |
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Citation | Sandner, A; Ngo, K; Schiebel, J; Pizarroso, AIM; Schmidt, L; Wenzel, B; Steinmetzer, T; Ostermann, A; Heine, A; Klebe, G How a Fragment Draws Attention to Selectivity Discriminating Features between the Related Proteases Trypsin and Thrombin. J Med Chem64:1611-1625 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Thyroid hormone receptor beta |
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Name: | Thyroid hormone receptor beta |
Synonyms: | ERBA2 | NR1A2 | Nuclear receptor subfamily 1 group A member 2 | THB_HUMAN | THR1 | THRB | c-erbA-2 | c-erbA-beta |
Type: | Receptor |
Mol. Mass.: | 52793.62 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1. |
Residue: | 461 |
Sequence: | MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
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BDBM50133531 |
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n/a |
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Name | BDBM50133531 |
Synonyms: | (S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid 3-chloro-benzylamide | 1-((S)-2-Amino-1-(R)-oxo-3-phenyl-propyl)-pyrrolidine-2-carboxylic acid 3-chloro-benzylamide | CHEMBL321130 | D-phenylalanyl-N-(3-chlorobenzyl)-L-prolinamide |
Type | Small organic molecule |
Emp. Form. | C21H24ClN3O2 |
Mol. Mass. | 385.887 |
SMILES | N[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1cccc(Cl)c1 |
Structure |
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