Reaction Details |
| Report a problem with these data |
Target | Sorbitol dehydrogenase |
---|
Ligand | BDBM50118709 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_223910 (CHEMBL844302) |
---|
IC50 | 7±n/a nM |
---|
Citation | Mylari, BL; Oates, PJ; Zembrowski, WJ; Beebe, DA; Conn, EL; Coutcher, JB; O'Gorman, MT; Linhares, MC; Withbroe, GJ A sorbitol dehydrogenase inhibitor of exceptional in vivo potency with a long duration of action: 1-(R)-[4-[4-(4,6-dimethyl[1,3,5]triazin-2-yl)- 2R,6S-dimethylpiperazin-1-yl]pyrimidin-2- yl]ethanol. J Med Chem45:4398-401 (2002) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Sorbitol dehydrogenase |
---|
Name: | Sorbitol dehydrogenase |
Synonyms: | DHSO_HUMAN | L-iditol 2-dehydrogenase | SORD |
Type: | PROTEIN |
Mol. Mass.: | 38332.20 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_223910 |
Residue: | 357 |
Sequence: | MAAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNF
IVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFC
ATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCG
AGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQL
GCKPEVTIECTGAEASIQAGIYATRSGGNLVLVGLGSEMTTVPLLHAAIREVDIKGVFRY
CNTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP
|
|
|
BDBM50118709 |
---|
n/a |
---|
Name | BDBM50118709 |
Synonyms: | 1-{4-[2,6-Dimethyl-4-(4-methyl-[1,3,5]triazin-2-yl)-piperazin-1-yl]-pyrimidin-2-yl}-ethanol | CHEMBL342697 |
Type | Small organic molecule |
Emp. Form. | C16H23N7O |
Mol. Mass. | 329.4001 |
SMILES | C[C@@H](O)c1nccc(n1)N1[C@@H](C)CN(C[C@H]1C)c1ncnc(C)n1 |
Structure |
|