| Reaction Details |
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 | Report a problem with these data |
| Target | Interstitial collagenase |
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| Ligand | BDBM50118971 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_106290 |
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| IC50 | 35±n/a nM |
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| Citation |  Nelson, FC; Delos Santos, E; Levin, JI; Chen, JM; Skotnicki, JS; DiJoseph, JF; Sharr, MA; Sung, A; Killar, LM; Cowling, R; Jin, G; Roth, CE; Albright, JD Benzodiazepine inhibitors of the MMPs and TACE. Bioorg Med Chem Lett12:2867-70 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Interstitial collagenase |
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| Name: | Interstitial collagenase |
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| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54010.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03956 |
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| Residue: | 469 |
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| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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| BDBM50118971 |
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| n/a |
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| Name | BDBM50118971 |
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| Synonyms: | 4-[4-(4-Chloro-phenoxy)-benzenesulfonyl]-1-(thiophene-2-carbonyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-3-carboxylic acid hydroxyamide | CHEMBL97788 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H22ClN3O6S2 |
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| Mol. Mass. | 584.063 |
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| SMILES | ONC(=O)C1CN(C(=O)c2cccs2)c2ccccc2CN1S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1 |
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| Structure | 
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